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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3frf XCF Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3frf XCFDihydrofolate reductase 1.5.1.3 1.012
3fyv XCFDihydrofolate reductase 1.5.1.3 0.826
3fy9 XCFDihydrofolate reductase 1.5.1.3 0.814
3fyw XCFDihydrofolate reductase 1.5.1.3 0.806
3m09 RARDihydrofolate reductase 1.5.1.3 0.768
2w9g TOPDihydrofolate reductase 1.5.1.3 0.750
4g8z TOPDihydrofolate reductase 1.5.1.3 0.745
1dg5 TOPDihydrofolate reductase 1.5.1.3 0.721
4ele 31IDihydrofolate reductase / 0.693
2w9h TOPDihydrofolate reductase 1.5.1.3 0.687
3fra I2HDihydrofolate reductase 1.5.1.3 0.685
1dyr TOPDihydrofolate reductase 1.5.1.3 0.684
3srw Q27Dihydrofolate reductase 1.5.1.3 0.681
4qi9 MTXDihydrofolate reductase / 0.663
3d80 Q22Dihydrofolate reductase 1.5.1.3 0.650