Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3frd DHF Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3frd DHFDihydrofolate reductase 1.5.1.3 1.077
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.825
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.807
4kjj FOLDihydrofolate reductase 1.5.1.3 0.806
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.800
2qk8 MTXDihydrofolate reductase / 0.791
5hi6 MTXDihydrofolate reductase / 0.780
1df7 MTXDihydrofolate reductase 1.5.1.3 0.776
1dhj MTXDihydrofolate reductase 1.5.1.3 0.775
3ia4 MTXDihydrofolate reductase / 0.775
3och 2MXDihydrofolate reductase 1.5.1.3 0.765
2zza FOLDihydrofolate reductase / 0.760
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.756
1dyj DDFDihydrofolate reductase 1.5.1.3 0.754
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.748
4i1n FOLDihydrofolate reductase 1.5.1.3 0.746
3drc MTXDihydrofolate reductase 1.5.1.3 0.745
1dre MTXDihydrofolate reductase 1.5.1.3 0.737
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.737
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.736
3dau MTXDihydrofolate reductase 1.5.1.3 0.736
1drf FOLDihydrofolate reductase 1.5.1.3 0.735
1u72 MTXDihydrofolate reductase 1.5.1.3 0.735
5ccc DDFDihydrofolate reductase 1.5.1.3 0.734
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.733
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.732
1ohj COPDihydrofolate reductase 1.5.1.3 0.731
2drc MTXDihydrofolate reductase 1.5.1.3 0.731
3dfr MTXDihydrofolate reductase 1.5.1.3 0.731
4fhb FOLDihydrofolate reductase 1.5.1.3 0.728
4p66 MTXDihydrofolate reductase / 0.726
7dfr FOLDihydrofolate reductase 1.5.1.3 0.723
1dhf FOLDihydrofolate reductase 1.5.1.3 0.722
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.720
1re7 FOLDihydrofolate reductase 1.5.1.3 0.719
1jol FFODihydrofolate reductase 1.5.1.3 0.716
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.715
1drb MTXDihydrofolate reductase 1.5.1.3 0.706
4qi9 MTXDihydrofolate reductase / 0.700
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.699
4keb FOLDihydrofolate reductase 1.5.1.3 0.698
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.698
3eig MTXDihydrofolate reductase 1.5.1.3 0.697
4p68 MTXDihydrofolate reductase / 0.697
1hfq MOTDihydrofolate reductase 1.5.1.3 0.692
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.692
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.692
1hfp MOTDihydrofolate reductase 1.5.1.3 0.687
1hfr MOTDihydrofolate reductase 1.5.1.3 0.686
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.682
4i13 FOLDihydrofolate reductase 1.5.1.3 0.682
1dls MTXDihydrofolate reductase 1.5.1.3 0.681
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.674
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.673
3ghw GHWDihydrofolate reductase 1.5.1.3 0.672
4m6k FOLDihydrofolate reductase 1.5.1.3 0.672
3tq9 MTXDihydrofolate reductase / 0.671
1dyi FOLDihydrofolate reductase 1.5.1.3 0.670
4dfr MTXDihydrofolate reductase 1.5.1.3 0.670
1e26 GPBDihydrofolate reductase 1.5.1.3 0.669
1jom FFODihydrofolate reductase 1.5.1.3 0.667
1u5a BIKL-lactate dehydrogenase 1.1.1.27 0.667
2w3m FOLDihydrofolate reductase 1.5.1.3 0.667
1dds MTXDihydrofolate reductase 1.5.1.3 0.666
1gir NDPIota toxin component Ia / 0.666
1ddr MTXDihydrofolate reductase 1.5.1.3 0.664
3dat MTXDihydrofolate reductase / 0.664
4x5f FOLDihydrofolate reductase 1.5.1.3 0.662
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.659
4iqq UMPThymidylate synthase / 0.659
4x5g FOLDihydrofolate reductase 1.5.1.3 0.657
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.656
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.655
4x5i FOLDihydrofolate reductase 1.5.1.3 0.655
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.654
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.652
4kfj FOLDihydrofolate reductase 1.5.1.3 0.650