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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3flk NAI Tartrate dehydrogenase/decarboxylase 1.1.1.93

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3flk NAITartrate dehydrogenase/decarboxylase 1.1.1.93 1.106
4f7i NAD3-isopropylmalate dehydrogenase 1.1.1.85 0.954
4xxv NAD3-isopropylmalate dehydrogenase / 0.903
4wuo NAD3-isopropylmalate dehydrogenase 1.1.1.85 0.875
2d4v NADIsocitrate dehydrogenase [NADP] / 0.815
2cmj NAPIsocitrate dehydrogenase [NADP] cytoplasmic 1.1.1.42 0.805
1xkd NAPIsocitrate dehydrogenase [NADP] / 0.795
2y42 NAD3-isopropylmalate dehydrogenase 1.1.1.85 0.779
2cmv NAPIsocitrate dehydrogenase [NADP] cytoplasmic 1.1.1.42 0.760
3inm NDPIsocitrate dehydrogenase [NADP] cytoplasmic 1.1.1.42 0.742
4aov NAPIsocitrate dehydrogenase [NADP] / 0.727
4umy NAPIsocitrate dehydrogenase [NADP] cytoplasmic 1.1.1.42 0.713
4umx NAPIsocitrate dehydrogenase [NADP] cytoplasmic 1.1.1.42 0.707
2d1c NAPIsocitrate dehydrogenase [NADP] 1.1.1.42 0.689
1t0l NAPIsocitrate dehydrogenase [NADP] cytoplasmic 1.1.1.42 0.679
4l03 NAPIsocitrate dehydrogenase [NADP] cytoplasmic 1.1.1.42 0.670
4l06 NAPIsocitrate dehydrogenase [NADP] cytoplasmic 1.1.1.42 0.650