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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3fkl FKL Mitogen-activated protein kinase 14

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3fkl FKLMitogen-activated protein kinase 14 / 1.199
4kin 1M8Mitogen-activated protein kinase 14 / 0.918
3itz P66Mitogen-activated protein kinase 14 / 0.851
4kip 1R9Mitogen-activated protein kinase 14 / 0.848
3iph G11Mitogen-activated protein kinase 14 / 0.841
4kiq 1RAMitogen-activated protein kinase 14 / 0.822
3e93 19BMitogen-activated protein kinase 14 / 0.814
2rg6 287Mitogen-activated protein kinase 14 / 0.813
3fsk RO6Mitogen-activated protein kinase 14 / 0.811
3rin I2OMitogen-activated protein kinase 14 / 0.809
4aa5 NQBMitogen-activated protein kinase 14 / 0.802
3e92 G6AMitogen-activated protein kinase 14 / 0.800
3u8w 09JMitogen-activated protein kinase 14 / 0.792
3gfe P37Mitogen-activated protein kinase 14 / 0.788
4aa0 AA0Mitogen-activated protein kinase 14 / 0.749
2rg5 279Mitogen-activated protein kinase 14 / 0.746
3fsf FSSMitogen-activated protein kinase 14 / 0.743
3bx5 304Mitogen-activated protein kinase 14 / 0.742
2zb0 GK3Mitogen-activated protein kinase 14 / 0.735
3cs9 NILTyrosine-protein kinase ABL1 2.7.10.2 0.728
3l8x N4DMitogen-activated protein kinase 14 / 0.724
3dt1 P40Mitogen-activated protein kinase 14 / 0.719
3mvm 39PMitogen-activated protein kinase 14 / 0.719
2hzi JINTyrosine-protein kinase ABL1 2.7.10.2 0.714
3s4q NK0Mitogen-activated protein kinase 14 / 0.712
4aac AAVMitogen-activated protein kinase 14 / 0.712
3lfa 1N1Mitogen-activated protein kinase 14 / 0.707
3kq7 KQ7Mitogen-activated protein kinase 14 / 0.704
3mvl 38PMitogen-activated protein kinase 14 / 0.691
3d7z GK5Mitogen-activated protein kinase 14 / 0.686
1m52 P17Tyrosine-protein kinase ABL1 2.7.10.2 0.685
2og8 1N8Tyrosine-protein kinase Lck 2.7.10.2 0.685
4eqc XR1Serine/threonine-protein kinase PAK 1 2.7.11.1 0.682
3ocg OCGMitogen-activated protein kinase 14 / 0.679
2zb1 GK4Mitogen-activated protein kinase 14 / 0.676
4uxq 0LIFibroblast growth factor receptor 4 2.7.10.1 0.676
3ds6 A17Mitogen-activated protein kinase 14 / 0.672
3p78 P78Mitogen-activated protein kinase 14 / 0.662
3ogk OGKCoronatine-insensitive protein 1 / 0.661
3hv5 R24Mitogen-activated protein kinase 14 / 0.659
4xey 1N1Tyrosine-protein kinase ABL1 2.7.10.2 0.658
3d83 GK6Mitogen-activated protein kinase 14 / 0.656
3gcv SS6Mitogen-activated protein kinase 14 / 0.656
2zva 1N1Tyrosine-protein kinase Lyn 2.7.10.2 0.651