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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3et7 349 Protein-tyrosine kinase 2-beta 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3et7 349Protein-tyrosine kinase 2-beta 2.7.10.2 0.989
3fzr 3JZProtein-tyrosine kinase 2-beta 2.7.10.2 0.852
4e5i 0N9Polymerase acidic protein / 0.744
3h3c P1EProtein-tyrosine kinase 2-beta 2.7.10.2 0.727
2xb7 GUIALK tyrosine kinase receptor 2.7.10.1 0.685
1gih 1PUCyclin-dependent kinase 2 2.7.11.22 0.676
2vgp AD6Aurora kinase B-A 2.7.11.1 0.675
2xnb Y8LCyclin-dependent kinase 2 2.7.11.22 0.667
4e93 GUITyrosine-protein kinase Fes/Fps 2.7.10.2 0.665
4eut BX7Serine/threonine-protein kinase TBK1 2.7.11.1 0.664
2jkk BI9Focal adhesion kinase 1 2.7.10.2 0.658
4dea NHIAurora kinase A 2.7.11.1 0.655
4fko 20KCyclin-dependent kinase 2 2.7.11.22 0.655