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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3dat MTX Dihydrofolate reductase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3dat MTXDihydrofolate reductase / 1.188
2qk8 MTXDihydrofolate reductase / 0.884
3ia4 MTXDihydrofolate reductase / 0.832
5hi6 MTXDihydrofolate reductase / 0.800
3och 2MXDihydrofolate reductase 1.5.1.3 0.786
1dra MTXDihydrofolate reductase 1.5.1.3 0.784
3drc MTXDihydrofolate reductase 1.5.1.3 0.783
3eig MTXDihydrofolate reductase 1.5.1.3 0.782
4p66 MTXDihydrofolate reductase / 0.768
2drc MTXDihydrofolate reductase 1.5.1.3 0.762
1drb MTXDihydrofolate reductase 1.5.1.3 0.754
3tq9 MTXDihydrofolate reductase / 0.753
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.751
3dau MTXDihydrofolate reductase 1.5.1.3 0.746
3dfr MTXDihydrofolate reductase 1.5.1.3 0.740
1dls MTXDihydrofolate reductase 1.5.1.3 0.738
1dhj MTXDihydrofolate reductase 1.5.1.3 0.735
1u70 MTXDihydrofolate reductase 1.5.1.3 0.732
1df7 MTXDihydrofolate reductase 1.5.1.3 0.730
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.729
1jol FFODihydrofolate reductase 1.5.1.3 0.724
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.720
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.714
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.712
1e26 GPBDihydrofolate reductase 1.5.1.3 0.709
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.708
4dfr MTXDihydrofolate reductase 1.5.1.3 0.707
1tdr MTXDihydrofolate reductase 1.5.1.3 0.706
1hfp MOTDihydrofolate reductase 1.5.1.3 0.702
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.701
1dre MTXDihydrofolate reductase 1.5.1.3 0.700
1hfq MOTDihydrofolate reductase 1.5.1.3 0.695
1dds MTXDihydrofolate reductase 1.5.1.3 0.693
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.688
1dhi MTXDihydrofolate reductase 1.5.1.3 0.684
4m7v RARDihydrofolate reductase / 0.684
4p68 MTXDihydrofolate reductase / 0.683
1ohk COPDihydrofolate reductase 1.5.1.3 0.679
1ddr MTXDihydrofolate reductase 1.5.1.3 0.672
3m08 RARDihydrofolate reductase 1.5.1.3 0.667
2fzj DH3Dihydrofolate reductase 1.5.1.3 0.666
4elg 52JDihydrofolate reductase / 0.666
1u72 MTXDihydrofolate reductase 1.5.1.3 0.665
3frd DHFDihydrofolate reductase 1.5.1.3 0.664
1ohj COPDihydrofolate reductase 1.5.1.3 0.663
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.662
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.662
2dhf DZFDihydrofolate reductase 1.5.1.3 0.661
1dyi FOLDihydrofolate reductase 1.5.1.3 0.660
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.659
4x5g FOLDihydrofolate reductase 1.5.1.3 0.658
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.655
1jom FFODihydrofolate reductase 1.5.1.3 0.654
3d80 Q22Dihydrofolate reductase 1.5.1.3 0.652
5ccc DDFDihydrofolate reductase 1.5.1.3 0.650