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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2z2w 770 Wee1-like protein kinase 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity
Align
2z2w 770Wee1-like protein kinase 2.7.10.2 1.041
3biz 61EWee1-like protein kinase 2.7.10.2 0.974
2in6 839Wee1-like protein kinase 2.7.10.2 0.943
2io6 330Wee1-like protein kinase 2.7.10.2 0.931
1x8b 824Wee1-like protein kinase 2.7.10.2 0.926
3bi6 396Wee1-like protein kinase 2.7.10.2 0.920
3cr0 809Wee1-like protein kinase 2.7.10.2 0.881
3cqe P91Wee1-like protein kinase 2.7.10.2 0.834
3cd3 STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.767
1q3d STUGlycogen synthase kinase-3 beta 2.7.11.26 0.708
2hy8 1STSerine/threonine-protein kinase PAK 1 2.7.11.1 0.704
2j0j 4STFocal adhesion kinase 1 2.7.10.2 0.699
4c58 824Cyclin-G-associated kinase 2.7.11.1 0.698
4qmy STUSerine/threonine-protein kinase 24 2.7.11.1 0.691
4fv9 E71Mitogen-activated protein kinase 1 2.7.11.24 0.684
2dq7 STUTyrosine-protein kinase Fyn 2.7.10.2 0.678
4mvf STUCalcium-dependent protein kinase 2 2.7.11.1 0.677
1pkd UCNCyclin-dependent kinase 2 2.7.11.22 0.673
5e8x STUTGF-beta receptor type-1 2.7.11.30 0.669
4qms 1N1Serine/threonine-protein kinase 24 2.7.11.1 0.667
3fi3 JK2Mitogen-activated protein kinase 10 2.7.11.24 0.664
5hes 032Mitogen-activated protein kinase kinase kinase 20 2.7.11.25 0.659
1nvq UCNSerine/threonine-protein kinase Chk1 2.7.11.1 0.655
3erk SB4Mitogen-activated protein kinase 1 2.7.11.24 0.653
4kiq 1RAMitogen-activated protein kinase 14 / 0.652
2buj STUSerine/threonine-protein kinase 16 / 0.650
4fr4 STUSerine/threonine-protein kinase 32A 2.7.11.1 0.650