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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2y42 NAD 3-isopropylmalate dehydrogenase 1.1.1.85

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2y42 NAD3-isopropylmalate dehydrogenase 1.1.1.85 0.959
4f7i NAD3-isopropylmalate dehydrogenase 1.1.1.85 0.834
4wuo NAD3-isopropylmalate dehydrogenase 1.1.1.85 0.814
4xxv NAD3-isopropylmalate dehydrogenase / 0.811
3flk NAITartrate dehydrogenase/decarboxylase 1.1.1.93 0.779
2d4v NADIsocitrate dehydrogenase [NADP] / 0.731
2cmv NAPIsocitrate dehydrogenase [NADP] cytoplasmic 1.1.1.42 0.698
1xkd NAPIsocitrate dehydrogenase [NADP] / 0.693
2cmj NAPIsocitrate dehydrogenase [NADP] cytoplasmic 1.1.1.42 0.673
2d1c NAPIsocitrate dehydrogenase [NADP] 1.1.1.42 0.672
4kzo NAPIsocitrate dehydrogenase [NADP] cytoplasmic 1.1.1.42 0.664
4aov NAPIsocitrate dehydrogenase [NADP] / 0.661
3inm NDPIsocitrate dehydrogenase [NADP] cytoplasmic 1.1.1.42 0.660
2r5t ANPSerine/threonine-protein kinase Sgk1 2.7.11.1 0.652
4l04 NAPIsocitrate dehydrogenase [NADP] cytoplasmic 1.1.1.42 0.651