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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2xke WI2 Serine/threonine-protein kinase Nek2 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2xke WI2Serine/threonine-protein kinase Nek2 2.7.11.1 0.995
2xk3 XK3Serine/threonine-protein kinase Nek2 2.7.11.1 0.858
2xkf BX1Serine/threonine-protein kinase Nek2 2.7.11.1 0.846
2wqo VGKSerine/threonine-protein kinase Nek2 2.7.11.1 0.833
2xk6 EQHSerine/threonine-protein kinase Nek2 2.7.11.1 0.781
2xk8 5R1Serine/threonine-protein kinase Nek2 2.7.11.1 0.752
2xkc 4VQSerine/threonine-protein kinase Nek2 2.7.11.1 0.746
2xkd T3MSerine/threonine-protein kinase Nek2 2.7.11.1 0.742
2e9o A58Serine/threonine-protein kinase Chk1 2.7.11.1 0.705
3bqr 4RBDeath-associated protein kinase 3 / 0.691
2ahc VNLChorismate pyruvate-lyase / 0.687
3axw TIDCasein kinase II subunit alpha 2.7.11.1 0.687
3pe1 3NGCasein kinase II subunit alpha 2.7.11.1 0.675
4egn TWOCytochrome P450 / 0.667
3rm7 19ZCyclin-dependent kinase 2 2.7.11.22 0.664
2xk7 30ESerine/threonine-protein kinase Nek2 2.7.11.1 0.660
4fsn A58Serine/threonine-protein kinase Chk1 2.7.11.1 0.658
3mhi J90Carbonic anhydrase 2 4.2.1.1 0.654
3nga 3NGCasein kinase II subunit alpha 2.7.11.1 0.650