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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2xch CKG 3-phosphoinositide-dependent protein kinase 1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2xch CKG3-phosphoinositide-dependent protein kinase 1 2.7.11.1 1.002
2xck MH43-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.817
2wip P49Cyclin-dependent kinase 2 2.7.11.22 0.717
1oec AA2Fibroblast growth factor receptor 2 / 0.688
5ap7 SVEDual specificity protein kinase TTK 2.7.12.1 0.686
3cjf SAVVascular endothelial growth factor receptor 2 2.7.10.1 0.685
2wxv WXVCyclin-dependent kinase 2 2.7.11.22 0.679
4bgh 3I6Cyclin-dependent kinase 2 2.7.11.22 0.675
2yac 937Serine/threonine-protein kinase PLK1 2.7.11.21 0.661
2hog 710Serine/threonine-protein kinase Chk1 2.7.11.1 0.660
4eut BX7Serine/threonine-protein kinase TBK1 2.7.11.1 0.658
2wih P48Cyclin-dependent kinase 2 2.7.11.22 0.656
2hxl 422Serine/threonine-protein kinase Chk1 2.7.11.1 0.655
4iwq 1FVSerine/threonine-protein kinase TBK1 2.7.11.1 0.655
4fv4 EK7Mitogen-activated protein kinase 1 2.7.11.24 0.654
2xb7 GUIALK tyrosine kinase receptor 2.7.10.1 0.652
1q8u H52cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651
2jko BIJFocal adhesion kinase 1 2.7.10.2 0.651