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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2wpa 889 Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2wpa 889Cyclin-dependent kinase 2 2.7.11.22 1.110
4o0r X4ZSerine/threonine-protein kinase PAK 1 2.7.11.1 0.721
2x4z X4ZSerine/threonine-protein kinase PAK 4 2.7.11.1 0.706
4bgq 38RCyclin-dependent kinase-like 5 2.7.11.22 0.698
2v7a 627Tyrosine-protein kinase ABL1 2.7.10.2 0.695
1v0o INRCell division control protein 2 homolog 2.7.11.22 0.693
3ddp RC8Cyclin-dependent kinase 2 2.7.11.22 0.693
4fki 09KCyclin-dependent kinase 2 2.7.11.22 0.692
1vyw 292Cyclin-dependent kinase 2 2.7.11.22 0.685
4nks 2M2Fibroblast growth factor receptor 1 / 0.683
4ek6 10KCyclin-dependent kinase 2 2.7.11.22 0.681
3pj8 404Cyclin-dependent kinase 2 2.7.11.22 0.680
1unl RRCCyclin-dependent-like kinase 5 2.7.11.1 0.679
4fkj 11KCyclin-dependent kinase 2 2.7.11.22 0.679
1vyz N5BCyclin-dependent kinase 2 2.7.11.22 0.677
4ks7 X4ZSerine/threonine-protein kinase PAK 6 2.7.11.1 0.676
1y91 CT9Cyclin-dependent kinase 2 2.7.11.22 0.672
2b53 D23Cyclin-dependent kinase 2 2.7.11.22 0.672
1e9h INRCyclin-dependent kinase 2 2.7.11.22 0.671
2a4l RRCCyclin-dependent kinase 2 2.7.11.22 0.671
3lq5 SLQCyclin-dependent kinase 9 2.7.11.22 0.670
2bts U32Cyclin-dependent kinase 2 2.7.11.22 0.669
3ddq RRCCyclin-dependent kinase 2 2.7.11.22 0.666
3dog NNNCyclin-dependent kinase 2 2.7.11.22 0.664
2c4g 514Cyclin-dependent kinase 2 2.7.11.22 0.662
2f2c AP9Cyclin-dependent kinase 6 2.7.11.22 0.661
3igg EFQCyclin-dependent kinase 2 2.7.11.22 0.659
2x1n X1NCyclin-dependent kinase 2 2.7.11.22 0.658
1g5s I17Cyclin-dependent kinase 2 2.7.11.22 0.654
4f64 0S8Fibroblast growth factor receptor 1 / 0.652
4f63 0S7Fibroblast growth factor receptor 1 / 0.650