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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2wmx ZY6 Serine/threonine-protein kinase Chk1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2wmx ZY6Serine/threonine-protein kinase Chk1 2.7.11.1 0.954
2wmw ZYWSerine/threonine-protein kinase Chk1 2.7.11.1 0.825
4e5i 0N9Polymerase acidic protein / 0.744
1zys 199Serine/threonine-protein kinase Chk1 2.7.11.1 0.712
4e5f 0N7Polymerase acidic protein / 0.660
4hvh 19RTyrosine-protein kinase JAK3 2.7.10.2 0.660
2xck MH43-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.659
3nyn SGVG protein-coupled receptor kinase 6 2.7.11.16 0.658
2wmv ZYVSerine/threonine-protein kinase Chk1 2.7.11.1 0.653
4jaj XU1Aurora kinase A 2.7.11.1 0.653
4e6q 0NVTyrosine-protein kinase JAK2 / 0.651