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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2vz6 FEF Calcium/calmodulin-dependent protein kinase type II subunit alpha 2.7.11.17

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2vz6 FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha 2.7.11.17 0.948
4e5i 0N9Polymerase acidic protein / 0.744
1e9h INRCyclin-dependent kinase 2 2.7.11.22 0.734
1unh IXMCyclin-dependent-like kinase 5 2.7.11.1 0.723
4fkv 61KCyclin-dependent kinase 2 2.7.11.22 0.705
4fks 46KCyclin-dependent kinase 2 2.7.11.22 0.704
3py0 SU9Cyclin-dependent kinase 2 2.7.11.22 0.696
1ke9 LS5Cyclin-dependent kinase 2 2.7.11.22 0.688
1q41 IXMGlycogen synthase kinase-3 beta 2.7.11.26 0.686
2x2m X2MProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.686
1ke7 LS3Cyclin-dependent kinase 2 2.7.11.22 0.684
1qpj STUTyrosine-protein kinase Lck 2.7.10.2 0.684
4fkp LS5Cyclin-dependent kinase 2 2.7.11.22 0.684
4aoj V4ZHigh affinity nerve growth factor receptor 2.7.10.1 0.683
4fx3 60KCyclin-dependent kinase 2 2.7.11.22 0.677
2x2k X2KProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.676
4fkr 45KCyclin-dependent kinase 2 2.7.11.22 0.670
4fkt 48KCyclin-dependent kinase 2 2.7.11.22 0.669
3eb0 DRKUncharacterized protein / 0.662
4e5f 0N7Polymerase acidic protein / 0.660
4fkw 62KCyclin-dependent kinase 2 2.7.11.22 0.658
3hzt J60Calmodulin-like domain protein kinase isoform 3 / 0.654
2hxq 373Serine/threonine-protein kinase Chk1 2.7.11.1 0.652