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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2vwz 7X6 Ephrin type-B receptor 4 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2vwz 7X6Ephrin type-B receptor 4 2.7.10.1 0.980
2vx0 7X7Ephrin type-B receptor 4 2.7.10.1 0.899
2vwy 7X5Ephrin type-B receptor 4 2.7.10.1 0.894
2vww 7X2Ephrin type-B receptor 4 2.7.10.1 0.878
2vx1 7X8Ephrin type-B receptor 4 2.7.10.1 0.875
2vwx 7X4Ephrin type-B receptor 4 2.7.10.1 0.873
2xvd AS6Ephrin type-B receptor 4 2.7.10.1 0.755
2vwu 7X1Ephrin type-B receptor 4 2.7.10.1 0.754
4e5i 0N9Polymerase acidic protein / 0.744
2x9f X9FEphrin type-B receptor 4 2.7.10.1 0.743
3unj 0BXCyclin-dependent kinase 2 2.7.11.22 0.709
4fv7 E94Mitogen-activated protein kinase 1 2.7.11.24 0.695
4i23 1C9Epidermal growth factor receptor 2.7.10.1 0.678
4mxy DB8Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.678
4mxz DB8Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.678
2itp AEEEpidermal growth factor receptor 2.7.10.1 0.664
2ivu ZD6Proto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.663
2itz IREEpidermal growth factor receptor 2.7.10.1 0.660
4e5f 0N7Polymerase acidic protein / 0.660
5amn DTQProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.660
4c3f 7KWTyrosine-protein kinase Lck 2.7.10.2 0.659
3unk 0BYCyclin-dependent kinase 2 2.7.11.22 0.657
2h8h H8HProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.653
4mxo DB8Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.653