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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2vti LZ3 Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2vti LZ3Cyclin-dependent kinase 2 2.7.11.22 0.980
4fkp LS5Cyclin-dependent kinase 2 2.7.11.22 0.860
4fkv 61KCyclin-dependent kinase 2 2.7.11.22 0.850
4fkt 48KCyclin-dependent kinase 2 2.7.11.22 0.825
4fkw 62KCyclin-dependent kinase 2 2.7.11.22 0.815
4fkq 42KCyclin-dependent kinase 2 2.7.11.22 0.808
1ke5 LS1Cyclin-dependent kinase 2 2.7.11.22 0.800
3ezv EZVCyclin-dependent kinase 2 2.7.11.22 0.793
3ezr EZRCyclin-dependent kinase 2 2.7.11.22 0.783
4fx3 60KCyclin-dependent kinase 2 2.7.11.22 0.763
1fvt 106Cyclin-dependent kinase 2 2.7.11.22 0.759
1ke9 LS5Cyclin-dependent kinase 2 2.7.11.22 0.753
4fks 46KCyclin-dependent kinase 2 2.7.11.22 0.752
1ke6 LS2Cyclin-dependent kinase 2 2.7.11.22 0.743
1gii 1PUCyclin-dependent kinase 2 2.7.11.22 0.742
1ke8 LS4Cyclin-dependent kinase 2 2.7.11.22 0.741
3qrt X14Cyclin-dependent kinase 2 2.7.11.22 0.735
2jds L20cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.726
1q41 IXMGlycogen synthase kinase-3 beta 2.7.11.26 0.724
1gih 1PUCyclin-dependent kinase 2 2.7.11.22 0.721
1pmv 537Mitogen-activated protein kinase 10 2.7.11.24 0.721
1vyz N5BCyclin-dependent kinase 2 2.7.11.22 0.719
4ek6 10KCyclin-dependent kinase 2 2.7.11.22 0.712
3py0 SU9Cyclin-dependent kinase 2 2.7.11.22 0.711
2qkr IXMCdc2-like CDK2/CDC28 like protein kinase / 0.710
4fki 09KCyclin-dependent kinase 2 2.7.11.22 0.704
3r8p Z46Cyclin-dependent kinase 2 2.7.11.22 0.702
2b52 D42Cyclin-dependent kinase 2 2.7.11.22 0.700
4bgh 3I6Cyclin-dependent kinase 2 2.7.11.22 0.700
1fvv 107Cyclin-dependent kinase 2 2.7.11.22 0.699
4fkg 4CKCyclin-dependent kinase 2 2.7.11.22 0.698
2b55 D31Cyclin-dependent kinase 2 2.7.11.22 0.694
2bts U32Cyclin-dependent kinase 2 2.7.11.22 0.694
3l9l L9LcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.694
3l9n L9NcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.691
1ckp PVBCyclin-dependent kinase 2 2.7.11.22 0.690
1urw I1PCyclin-dependent kinase 2 2.7.11.22 0.690
4fkr 45KCyclin-dependent kinase 2 2.7.11.22 0.689
3nun JMZ3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.686
2gdo 12CSerine/threonine-protein kinase Chk1 2.7.11.1 0.684
2r3l SCWCyclin-dependent kinase 2 2.7.11.22 0.683
3l9m L9McAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.683
1ke7 LS3Cyclin-dependent kinase 2 2.7.11.22 0.682
2r64 740Cyclin-dependent kinase 2 2.7.11.22 0.682
2uzt SS3cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.681
3lfq A28Cyclin-dependent kinase 2 2.7.11.22 0.681
2c6t DT5Cyclin-dependent kinase 2 2.7.11.22 0.679
3qzg X67Cyclin-dependent kinase 2 2.7.11.22 0.678
3ti1 B49Cyclin-dependent kinase 2 2.7.11.22 0.677
2c6l DT4Cyclin-dependent kinase 2 2.7.11.22 0.676
2w17 I19Cyclin-dependent kinase 2 2.7.11.22 0.675
4agu D15Cyclin-dependent kinase-like 1 / 0.675
4ez5 0RSCyclin-dependent kinase 6 2.7.11.22 0.675
2b54 D05Cyclin-dependent kinase 2 2.7.11.22 0.674
1e9h INRCyclin-dependent kinase 2 2.7.11.22 0.671
1uv5 BRWGlycogen synthase kinase-3 beta 2.7.11.26 0.671
1v0o INRCell division control protein 2 homolog 2.7.11.22 0.671
2vth LZ2Cyclin-dependent kinase 2 2.7.11.22 0.671
2vtq LZACyclin-dependent kinase 2 2.7.11.22 0.671
1oit HDTCyclin-dependent kinase 2 2.7.11.22 0.670
3kkv B99cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.670
4fsq HK3Serine/threonine-protein kinase Chk1 2.7.11.1 0.669
3vqh IQBcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.668
1dm2 HMDCyclin-dependent kinase 2 2.7.11.22 0.667
2r3g SC9Cyclin-dependent kinase 2 2.7.11.22 0.665
3lfn A27Cyclin-dependent kinase 2 2.7.11.22 0.664
2uzv SS5cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.663
3bgq VX2Serine/threonine-protein kinase pim-1 2.7.11.1 0.663
3nux 3NVCyclin-dependent kinase 6 2.7.11.22 0.663
4ftl H0KSerine/threonine-protein kinase Chk1 2.7.11.1 0.663
2r3j SCJCyclin-dependent kinase 2 2.7.11.22 0.662
2vtj LZ4Cyclin-dependent kinase 2 2.7.11.22 0.658
2w06 FRVCyclin-dependent kinase 2 2.7.11.22 0.658
3cy3 JN5Serine/threonine-protein kinase pim-1 2.7.11.1 0.658
3qql X03Cyclin-dependent kinase 2 2.7.11.22 0.658
3qtq X35Cyclin-dependent kinase 2 2.7.11.22 0.658
3pxy JWSCyclin-dependent kinase 2 2.7.11.22 0.657
1pxp CK8Cyclin-dependent kinase 2 2.7.11.22 0.656
2r3p 3SCCyclin-dependent kinase 2 2.7.11.22 0.656
3sw4 18KCyclin-dependent kinase 2 2.7.11.22 0.656
3ql8 X01Cyclin-dependent kinase 2 2.7.11.22 0.654
1w0x OLOCyclin-dependent kinase 2 2.7.11.22 0.653
2oh0 2PYcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.653
2xx4 13IATP-dependent molecular chaperone HSP82 / 0.653
1pxo CK7Cyclin-dependent kinase 2 2.7.11.22 0.652
1vyw 292Cyclin-dependent kinase 2 2.7.11.22 0.652
4fko 20KCyclin-dependent kinase 2 2.7.11.22 0.652
4fsm HK1Serine/threonine-protein kinase Chk1 2.7.11.1 0.652
2a0c CK9Cyclin-dependent kinase 2 2.7.11.22 0.651
4ag8 AXIVascular endothelial growth factor receptor 2 2.7.10.1 0.651
2f7e 2EAcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.650
4eh7 0OOMitogen-activated protein kinase 14 / 0.650