Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2v3w TPP Benzoylformate decarboxylase 4.1.1.7

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2v3w TPPBenzoylformate decarboxylase 4.1.1.7 1.165
3fzn D7KBenzoylformate decarboxylase 4.1.1.7 1.090
4jub TPPBenzoylformate decarboxylase 4.1.1.7 1.071
4juf TPPBenzoylformate decarboxylase 4.1.1.7 1.046
4juc TPPBenzoylformate decarboxylase 4.1.1.7 1.037
1po7 TZDBenzoylformate decarboxylase 4.1.1.7 1.026
4ju9 TZDBenzoylformate decarboxylase 4.1.1.7 1.024
5dgt TZDBenzoylformate decarboxylase 4.1.1.7 1.024
4k9n TZDBenzoylformate decarboxylase 4.1.1.7 1.020
4qel TZDBenzoylformate decarboxylase 4.1.1.7 1.020
3fsj D7KBenzoylformate decarboxylase 4.1.1.7 1.012
4mq5 TPPBenzoylformate decarboxylase 4.1.1.7 0.994
4mpr TPPBenzoylformate decarboxylase 4.1.1.7 0.993
4k9o TPPBenzoylformate decarboxylase 4.1.1.7 0.988
4mpp TZDBenzoylformate decarboxylase 4.1.1.7 0.974
1mcz TDPBenzoylformate decarboxylase 4.1.1.7 0.968
4k9p TPPBenzoylformate decarboxylase 4.1.1.7 0.965
4gm4 TZDBenzoylformate decarboxylase 4.1.1.7 0.952
2fwn TDPBenzoylformate decarboxylase 4.1.1.7 0.946
4gg1 TZDBenzoylformate decarboxylase 4.1.1.7 0.942
4mzx TZDBenzoylformate decarboxylase 4.1.1.7 0.942
1bfd TPPBenzoylformate decarboxylase 4.1.1.7 0.939
4jd5 TZDBenzoylformate decarboxylase 4.1.1.7 0.939
4gm0 TZDBenzoylformate decarboxylase 4.1.1.7 0.923
4ju8 TZDBenzoylformate decarboxylase 4.1.1.7 0.894
4gm1 TZDBenzoylformate decarboxylase 4.1.1.7 0.890
2w93 TPPPyruvate decarboxylase isozyme 1 / 0.863
2vk8 TPPPyruvate decarboxylase isozyme 1 / 0.841
1pyd TDPPyruvate decarboxylase isozyme 1 / 0.834
2vk4 TPPPyruvate decarboxylase 4.1.1.1 0.826
2ji7 OXTOxalyl-CoA decarboxylase 4.1.1.8 0.825
1pox TPPPyruvate oxidase 1.2.3.3 0.816
2q5o TPWIndole-3-pyruvate decarboxylase 4.1.1.74 0.814
1pvd TPPPyruvate decarboxylase isozyme 1 / 0.813
4cok TPPPyruvate decarboxylase / 0.802
3hwx TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.799
5eja TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.796
4zp1 TPPPyruvate decarboxylase 4.1.1.1 0.791
5eso TDP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.790
1ols TDP2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 1.2.4.4 0.786
2ihu TP9N(2)-(2-carboxyethyl)arginine synthase / 0.784
2uza HTLPyruvate synthase / 0.781
5ej9 TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.779
5ej6 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.778
1jsc TPPAcetolactate synthase catalytic subunit, mitochondrial 2.2.1.6 0.769
1ni4 TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1.2.4.1 0.767
1ni4 TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial 1.2.4.1 0.767
3oe1 TDLPyruvate decarboxylase 4.1.1.1 0.767
5ej5 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.766
2c3y HTLPyruvate synthase / 0.762
2qta TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.759
5esd TDP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.757
3lq2 TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.756
1y9d TPPPyruvate oxidase 1.2.3.3 0.753
2ez9 TDKPyruvate oxidase 1.2.3.3 0.752
1v11 TDP2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 1.2.4.4 0.748
2c3p 1TPPyruvate synthase / 0.748
5c4i TPPOxalate oxidoreductase subunit alpha / 0.743
5c4i TPPOxalate oxidoreductase subunit beta / 0.743
2ji9 TPWOxalyl-CoA decarboxylase 4.1.1.8 0.741
1ovm TPPIndole-3-pyruvate decarboxylase 4.1.1.74 0.739
2x7j TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.738
1umc TDP2-oxoisovalerate dehydrogenase subunit alpha 1.2.4.4 0.735
1umc TDP2-oxoisovalerate dehydrogenase subunit beta 1.2.4.4 0.735
1pow TPPPyruvate oxidase 1.2.3.3 0.733
3lq4 TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.733
2q5q TPWIndole-3-pyruvate decarboxylase 4.1.1.74 0.730
2g28 TDKPyruvate dehydrogenase E1 component 1.2.4.1 0.728
3dv0 TPWPyruvate dehydrogenase E1 component subunit alpha 1.2.4.1 0.726
3dv0 TPWPyruvate dehydrogenase E1 component subunit beta 1.2.4.1 0.726
3exh TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1.2.4.1 0.723
3exh TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial 1.2.4.1 0.723
3ahi HTLProbable phosphoketolase / 0.721
5ahk TPPAcetolactate synthase II, large subunit / 0.721
1l8a TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.718
2c31 TZDOxalyl-CoA decarboxylase 4.1.1.8 0.718
3ey9 TDPPyruvate dehydrogenase [ubiquinone] 1.2.5.1 0.717
1w88 TDPPyruvate dehydrogenase E1 component subunit alpha 1.2.4.1 0.715
1w88 TDPPyruvate dehydrogenase E1 component subunit beta 1.2.4.1 0.715
1qpb TPPPyruvate decarboxylase isozyme 1 / 0.709
2ji6 TPWOxalyl-CoA decarboxylase 4.1.1.8 0.708
4qpz TPPBenzaldehyde lyase / 0.708
3ahj TPPProbable phosphoketolase / 0.706
3zhq TPPMultifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.706
3ahe THDProbable phosphoketolase / 0.705
1itz TPPTransketolase, chloroplastic 2.2.1.1 0.704
2j9f THV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 1.2.4.4 0.704
2j9f THV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial 1.2.4.4 0.704
2ag0 TPPBenzaldehyde lyase / 0.703
2ezt TDMPyruvate oxidase 1.2.3.3 0.701
5exd TPPOxalate oxidoreductase subunit alpha / 0.700
5exd TPPOxalate oxidoreductase subunit beta / 0.700
2c3o TPPPyruvate synthase / 0.698
5ej7 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.698
2pan TDPGlyoxylate carboligase 4.1.1.47 0.696
1rp7 TZDPyruvate dehydrogenase E1 component 1.2.4.1 0.694
2iea TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.693
2jla TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.692
2uz1 TPPBenzaldehyde lyase / 0.692
5ej8 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.691
1ngs TPPTransketolase 1 2.2.1.1 0.690
3upt TPPTransketolase / 0.690
2pz8 APCNH(3)-dependent NAD(+) synthetase / 0.688
3iaf TPPBenzaldehyde lyase / 0.687
2jlc TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.686
5ej4 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.686
1upc TPPN(2)-(2-carboxyethyl)arginine synthase / 0.685
3iae D7KBenzaldehyde lyase / 0.685
3zhr TPPMultifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.681
3zhv TDWMultifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.678
2g25 TDKPyruvate dehydrogenase E1 component 1.2.4.1 0.677
2c42 TPPPyruvate synthase / 0.676
3m6l TPPTransketolase / 0.676
1gpu THDTransketolase 1 2.2.1.1 0.675
3exf TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1.2.4.1 0.675
3exf TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial 1.2.4.1 0.675
3zhu TD8Multifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.675
3duf R1TPyruvate dehydrogenase E1 component subunit alpha 1.2.4.1 0.674
3duf R1TPyruvate dehydrogenase E1 component subunit beta 1.2.4.1 0.674
2jib TPPOxalyl-CoA decarboxylase 4.1.1.8 0.673
3d7k D7KBenzaldehyde lyase / 0.673
3zhs TD6Multifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.672
2iht TPPN(2)-(2-carboxyethyl)arginine synthase / 0.670
3eya TDPPyruvate dehydrogenase [ubiquinone] 1.2.5.1 0.668
3m34 TPPTransketolase / 0.666
1ay0 TPPTransketolase 1 2.2.1.1 0.665
4g0n GNPGTPase HRas / 0.663
3tkl GTPRas-related protein Rab-1A / 0.662
3zfd ANPChromosome-associated kinesin KIF4 / 0.662
1upb TPPN(2)-(2-carboxyethyl)arginine synthase / 0.661
2olr ATPPhosphoenolpyruvate carboxykinase (ATP) / 0.661
2ihv TPPN(2)-(2-carboxyethyl)arginine synthase / 0.660
3rim TPPTransketolase 2.2.1.1 0.660
1ky2 GNPGTP-binding protein YPT7 / 0.659
1tkc M6TTransketolase 1 2.2.1.1 0.653
2bku GTPGTP-binding nuclear protein Ran / 0.653
2o1x TDP1-deoxy-D-xylulose-5-phosphate synthase 2.2.1.7 0.653
3tgp GNPGTPase HRas / 0.653
2r8o T5XTransketolase 1 / 0.651
2r8p T6FTransketolase 1 / 0.650
3ftq GNPSeptin-2 / 0.650
4db1 ANPMyosin-7 / 0.650
4qnr ATPPsp operon transcriptional activator / 0.650