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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2uzu L20 cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2uzu L20cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.075
2jds L20cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.855
2uzt SS3cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.804
2ojf 4PYcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.803
2jdv L20cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.797
2uzv SS5cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.771
3kkv B99cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.767
2uzw SS4cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.760
3l9m L9McAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.754
2oh0 2PYcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.721
3l9l L9LcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.716
3l9n L9NcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.704
4agu D15Cyclin-dependent kinase-like 1 / 0.691
3ti1 B49Cyclin-dependent kinase 2 2.7.11.22 0.687
4ks8 B49Serine/threonine-protein kinase PAK 6 2.7.11.1 0.681
3v8s 0HDRho-associated protein kinase 1 2.7.11.1 0.679
2f7x 4EAcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.671
2gnl H52cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.670
2hk5 1BMTyrosine-protein kinase HCK 2.7.10.2 0.669
1p2a 5BNCyclin-dependent kinase 2 2.7.11.22 0.667
4elb 34SDihydrofolate reductase / 0.667
2vth LZ2Cyclin-dependent kinase 2 2.7.11.22 0.664
3mvj XFEcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.660
1rek B8LcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.657
4fkg 4CKCyclin-dependent kinase 2 2.7.11.22 0.657
2jam J60Calcium/calmodulin-dependent protein kinase type 1G 2.7.11.17 0.653
4fsq HK3Serine/threonine-protein kinase Chk1 2.7.11.1 0.653
3hzt J60Calmodulin-like domain protein kinase isoform 3 / 0.652
4ftl H0KSerine/threonine-protein kinase Chk1 2.7.11.1 0.652