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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2uyy NA7 Putative oxidoreductase GLYR1 1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2uyy NA7Putative oxidoreductase GLYR1 1 1.077
2cvz NDP3-hydroxyisobutyrate dehydrogenase / 0.753
1wp4 NDP3-hydroxyisobutyrate dehydrogenase / 0.739
3pef NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.711
3pdu NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.707
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 0.689
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 0.688
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 0.675
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.674
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 0.674
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 0.674
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 0.673
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 0.672
4cpd NADAlcohol dehydrogenase / 0.669
4oqy NDP(S)-imine reductase / 0.668
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.660
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.659
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 0.655