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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2r5t ANP Serine/threonine-protein kinase Sgk1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2r5t ANPSerine/threonine-protein kinase Sgk1 2.7.11.1 1.094
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.696
4xxv NAD3-isopropylmalate dehydrogenase / 0.678
5l8l ADPAurora kinase A 2.7.11.1 0.677
1mb9 ATPCarboxyethyl-arginine beta-lactam-synthase 6.3.3.4 0.674
1n75 ATPGlutamate--tRNA ligase 6.1.1.17 0.671
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.670
3dyh 721Farnesyl pyrophosphate synthase / 0.668
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.663
2osb AP5Adenylate kinase / 0.662
5l8j ADPAurora kinase A 2.7.11.1 0.662
3vth APCCarbamoyltransferase / 0.660
2d4v NADIsocitrate dehydrogenase [NADP] / 0.659
4wuo NAD3-isopropylmalate dehydrogenase 1.1.1.85 0.657
1oe0 TTPDeoxynucleoside kinase / 0.656
4gvz ADPArginine kinase 2.7.3.3 0.655
4kqs RISFarnesyl pyrophosphate synthase 2.5.1.10 0.655
2olq ATPPhosphoenolpyruvate carboxykinase (ATP) / 0.652
2y42 NAD3-isopropylmalate dehydrogenase 1.1.1.85 0.652
4fcw ADPChaperone protein ClpB / 0.650
4h5e YS4Farnesyl pyrophosphate synthase 2.5.1.10 0.650
5d9j 0N8Polymerase acidic protein / 0.650