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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2prh 238 Dihydroorotate dehydrogenase (quinone), mitochondrial 1.3.5.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2prh 238Dihydroorotate dehydrogenase (quinone), mitochondrial 1.3.5.2 1.249
1uuo BRFDihydroorotate dehydrogenase (quinone), mitochondrial 1.3.5.2 0.821
1d3g BREDihydroorotate dehydrogenase (quinone), mitochondrial 1.3.5.2 0.819
2b0m 201Dihydroorotate dehydrogenase (quinone), mitochondrial 1.3.5.2 0.782
1toj HCIAspartate aminotransferase 2.6.1.1 0.678
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.675
2tpl HPPTyrosine phenol-lyase 4.1.99.2 0.669
4m6l 21VDihydrofolate reductase 1.5.1.3 0.667
1ci7 UMPThymidylate synthase 2.1.1.45 0.665
1toi HCIAspartate aminotransferase 2.6.1.1 0.663
2p1o NLAProtein TRANSPORT INHIBITOR RESPONSE 1 / 0.659
3lnc 5GPGuanylate kinase / 0.654
2rds 1PL1-deoxypentalenic acid 11-beta-hydroxylase 1.14.11.35 0.650