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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2piu DHT Androgen receptor

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2piu DHTAndrogen receptor / 1.237
2piv DHTAndrogen receptor / 1.180
1t7t DHTAndrogen receptor / 1.164
1t63 DHTAndrogen receptor / 1.141
1t74 DHTAndrogen receptor / 1.141
2pit DHTAndrogen receptor / 1.138
1t7f DHTAndrogen receptor / 1.131
4oez DHTAndrogen receptor / 1.123
2pkl DHTAndrogen receptor / 1.100
2qpy DHTAndrogen receptor / 1.089
2pir DHTAndrogen receptor / 1.069
1t5z DHTAndrogen receptor / 1.054
1t7r DHTAndrogen receptor / 1.054
2piq DHTAndrogen receptor / 1.037
2ylq TESAndrogen receptor / 0.979
2q7j TESAndrogen receptor / 0.974
2yhd TESAndrogen receptor / 0.972
2pio DHTAndrogen receptor / 0.920
2pnu ENMAndrogen receptor / 0.917
4ofr DHTAndrogen receptor / 0.883
1xow R18Androgen receptor / 0.869
4oey DHTAndrogen receptor / 0.858
2ama DHTAndrogen receptor / 0.848
1t79 DHTAndrogen receptor / 0.840
2q7l TESAndrogen receptor / 0.837
4oea DHTAndrogen receptor / 0.834
1t65 DHTAndrogen receptor / 0.819
2q7i TESAndrogen receptor / 0.802
2ylp TESAndrogen receptor / 0.798
4ofu DHTAndrogen receptor / 0.757
1t76 DHTAndrogen receptor / 0.755
1xj7 DHTAndrogen receptor / 0.741
1xq3 R18Androgen receptor / 0.732
3zqt TESAndrogen receptor / 0.725
2ylo TESAndrogen receptor / 0.722
4hlw TESAndrogen receptor / 0.720
2j7x ESTEstrogen receptor beta / 0.714
1t73 DHTAndrogen receptor / 0.710
4oed DHTAndrogen receptor / 0.705
2aib ERGBeta-elicitin cinnamomin / 0.704
4e5l DBHPolymerase acidic protein / 0.701
1jtv TESEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.700
2g5o DRQEstrogen receptor / 0.696
2pip DHTAndrogen receptor / 0.696
2piw DHTAndrogen receptor / 0.696
1coy ANDCholesterol oxidase 1.1.3.6 0.695
2q7k TESAndrogen receptor / 0.692
2z4j DHTAndrogen receptor / 0.688
1xf0 ASDAldo-keto reductase family 1 member C3 / 0.687
3nhx ASDSteroid Delta-isomerase 5.3.3.1 0.681
3w5t LHPVitamin D3 receptor / 0.679
3w5p 4OAVitamin D3 receptor / 0.676
2aa2 AS4Mineralocorticoid receptor / 0.675
3s79 ASDAromatase 1.14.14.14 0.674
2yja ESTEstrogen receptor / 0.671
4q0a 4OAVitamin D3 receptor A / 0.669
1lri CLRBeta-elicitin cryptogein / 0.668
1y5r C0RCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.668
4j26 ESTEstrogen receptor beta / 0.667
2ocf ESTEstrogen receptor / 0.666
3nbr ASDSteroid Delta-isomerase 5.3.3.1 0.666
4ftn 2HKSerine/threonine-protein kinase Chk1 2.7.11.1 0.666
5dx3 ESTEstrogen receptor / 0.666
3iw1 ASDSteroid C26-monooxygenase 1.14.13.141 0.665
4k7a DHTAndrogen receptor / 0.664
4j24 ESTEstrogen receptor beta / 0.663
1e3k R18Progesterone receptor / 0.662
3bej MUFBile acid receptor / 0.662
2aa7 1CAMineralocorticoid receptor / 0.660
2aax PDNMineralocorticoid receptor / 0.656
2j7y E3OEstrogen receptor beta / 0.656
3uzx AOX3-oxo-5-beta-steroid 4-dehydrogenase / 0.656
3oll ESTEstrogen receptor beta / 0.655
3ols ESTEstrogen receptor beta / 0.654
2yne NHWGlycylpeptide N-tetradecanoyltransferase / 0.653
1qyw 5SDEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.652
1xu7 CPSCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.651
2dq7 STUTyrosine-protein kinase Fyn 2.7.10.2 0.651
2pix DHTAndrogen receptor / 0.651