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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2pdl TOL Aldose reductase 1.1.1.21

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2pdl TOLAldose reductase 1.1.1.21 1.057
1ah3 TOLAldose reductase 1.1.1.21 0.884
2fzd TOLAldose reductase 1.1.1.21 0.822
2fzb TOLAldose reductase 1.1.1.21 0.766
3m4h 388Aldose reductase 1.1.1.21 0.705
3lbo LDTAldose reductase 1.1.1.21 0.700
3ght LDTAldose reductase 1.1.1.21 0.699
3ghu LDTAldose reductase 1.1.1.21 0.698
2ipw 2CLAldose reductase 1.1.1.21 0.695
3ld5 LDTAldose reductase 1.1.1.21 0.695
2i16 LDTAldose reductase 1.1.1.21 0.679
2qxw LDTAldose reductase 1.1.1.21 0.679
3ghr LDTAldose reductase 1.1.1.21 0.679
2pdc 393Aldose reductase 1.1.1.21 0.678
2pdj 393Aldose reductase 1.1.1.21 0.677
1us0 LDTAldose reductase 1.1.1.21 0.674
1zua TOLAldo-keto reductase family 1 member B10 1.1.1 0.668
3m64 393Aldose reductase 1.1.1.21 0.667
2iki 388Aldose reductase 1.1.1.21 0.666
2ikh LITAldose reductase 1.1.1.21 0.662
2ikj 393Aldose reductase 1.1.1.21 0.662
2nvc ITAAldose reductase 1.1.1.21 0.662
3mc5 393Aldose reductase 1.1.1.21 0.661
3ghs LDTAldose reductase 1.1.1.21 0.656
3lz5 LDTAldose reductase 1.1.1.21 0.655