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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2jji 0QS Endothiapepsin 3.4.23.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2jji 0QSEndothiapepsin 3.4.23.22 1.385
1od1 0QSEndothiapepsin 3.4.23.22 1.212
2jjj 0QSEndothiapepsin 3.4.23.22 1.212
1gvt 2ZSEndothiapepsin 3.4.23.22 1.007
1gvw 0EMEndothiapepsin 3.4.23.22 0.971
1e82 M90Endothiapepsin 3.4.23.22 0.967
1e81 M91Endothiapepsin 3.4.23.22 0.943
1e80 0GQEndothiapepsin 3.4.23.22 0.912
1gvv 0GMEndothiapepsin 3.4.23.22 0.816
1ppk IVVPenicillopepsin-1 3.4.23.20 0.801
1ppl 1Z7Penicillopepsin-1 3.4.23.20 0.798
1bxo PP7Penicillopepsin-1 3.4.23.20 0.797
1psa 0ZLPepsin A 3.4.23.1 0.790
1bxq PP8Penicillopepsin-1 3.4.23.20 0.786
1xe5 5FEPlasmepsin-2 3.4.23.39 0.783
1qrp HH0Pepsin A-4 3.4.23.1 0.771
2g94 ZPQBeta-secretase 1 3.4.23.46 0.771
1eag A70Candidapepsin-2 3.4.23.24 0.762
3d91 REMRenin 3.4.23.15 0.756
1rne C60Renin 3.4.23.15 0.752
3prs RITEndothiapepsin 3.4.23.22 0.742
1ppm 0P1Penicillopepsin-1 3.4.23.20 0.732
3cid 318Beta-secretase 1 3.4.23.46 0.729
1zap A70Candidapepsin-2 3.4.23.24 0.725
2web PP4Penicillopepsin-1 3.4.23.20 0.724
1bim 0QBRenin 3.4.23.15 0.721
1bil 0IURenin 3.4.23.15 0.717
3k5g BJCBeta-secretase 1 3.4.23.46 0.717
3veu 0GOBeta-secretase 1 3.4.23.46 0.717
3duy AFJBeta-secretase 1 3.4.23.46 0.706
3dv5 BAVBeta-secretase 1 3.4.23.46 0.700
2xfj VG5Beta-secretase 1 3.4.23.46 0.699
3k5d XLIBeta-secretase 1 3.4.23.46 0.697
3own 3OXRenin 3.4.23.15 0.696
2iqg F2IBeta-secretase 1 3.4.23.46 0.692
3r2f PB0Beta-secretase 1 3.4.23.46 0.692
3lpj Z75Beta-secretase 1 3.4.23.46 0.689
2wf1 ZY1Beta-secretase 1 3.4.23.46 0.687
3ohf 3HFBeta-secretase 1 3.4.23.46 0.686
4ke0 1R8Beta-secretase 1 3.4.23.46 0.685
3cic 316Beta-secretase 1 3.4.23.46 0.683
2fdp FRPBeta-secretase 1 3.4.23.46 0.681
4k8s 1QTBeta-secretase 1 3.4.23.46 0.681
4dus 0MPBeta-secretase 1 3.4.23.46 0.680
3pww ROCEndothiapepsin 3.4.23.22 0.678
2qzl IXSBeta-secretase 1 3.4.23.46 0.676
2p8h MY9Beta-secretase 1 3.4.23.46 0.675
2p83 MR0Beta-secretase 1 3.4.23.46 0.673
4ke1 1R6Beta-secretase 1 3.4.23.46 0.673
4fco 0U4Beta-secretase 1 3.4.23.46 0.671
1w51 L01Beta-secretase 1 3.4.23.46 0.670
1w6h TITPlasmepsin-2 3.4.23.39 0.669
3nsh 957Beta-secretase 1 3.4.23.46 0.669
4i0i 957Beta-secretase 1 3.4.23.46 0.669
2vj9 VG7Beta-secretase 1 3.4.23.46 0.667
3el9 DR7Gag-Pol polyprotein 3.4.23.16 0.667
2b8l 5HABeta-secretase 1 3.4.23.46 0.666
2vij C44Beta-secretase 1 3.4.23.46 0.666
4dh6 0KNBeta-secretase 1 3.4.23.46 0.665
3k5f AYHBeta-secretase 1 3.4.23.46 0.662
2f3e AXQBeta-secretase 1 3.4.23.46 0.658
2fxd DR7Pol polyprotein / 0.658
4dpi 0N1Beta-secretase 1 3.4.23.46 0.658
3d1y ROCGag-Pol polyprotein 3.4.23.16 0.656
2nmy ROCProtease / 0.655
3ohh 3HHBeta-secretase 1 3.4.23.46 0.653
1hxb ROCGag-Pol polyprotein 3.4.23.16 0.650
1siv PSIGag-Pol polyprotein / 0.650