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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2jam J60 Calcium/calmodulin-dependent protein kinase type 1G 2.7.11.17

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2jam J60Calcium/calmodulin-dependent protein kinase type 1G 2.7.11.17 0.941
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
3ti1 B49Cyclin-dependent kinase 2 2.7.11.22 0.704
4fkr 45KCyclin-dependent kinase 2 2.7.11.22 0.698
4ks8 B49Serine/threonine-protein kinase PAK 6 2.7.11.1 0.693
1p2a 5BNCyclin-dependent kinase 2 2.7.11.22 0.672
2xik J60Serine/threonine-protein kinase 25 2.7.11.1 0.669
4agd B49Vascular endothelial growth factor receptor 2 2.7.10.1 0.669
2qkr IXMCdc2-like CDK2/CDC28 like protein kinase / 0.664
2z7q ACPRibosomal protein S6 kinase alpha-1 2.7.11.1 0.663
2cgw 3C3Serine/threonine-protein kinase Chk1 2.7.11.1 0.661
4e5f 0N7Polymerase acidic protein / 0.660
4fkq 42KCyclin-dependent kinase 2 2.7.11.22 0.660
2wkm PFYHepatocyte growth factor receptor 2.7.10.1 0.657
1ke5 LS1Cyclin-dependent kinase 2 2.7.11.22 0.656
2uzu L20cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.653