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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2j9m PY8 Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2j9m PY8Cyclin-dependent kinase 2 2.7.11.22 0.943
2jkk BI9Focal adhesion kinase 1 2.7.10.2 0.719
2x1n X1NCyclin-dependent kinase 2 2.7.11.22 0.691
4bgh 3I6Cyclin-dependent kinase 2 2.7.11.22 0.684
4d58 BI9Focal adhesion kinase 1 2.7.10.2 0.675
4dea NHIAurora kinase A 2.7.11.1 0.673
3uo5 0BXAurora kinase A 2.7.11.1 0.671
4e93 GUITyrosine-protein kinase Fes/Fps 2.7.10.2 0.667
2xb7 GUIALK tyrosine kinase receptor 2.7.10.1 0.661
4d4s BI9Focal adhesion kinase 1 2.7.10.2 0.661
4ji9 1M3Tyrosine-protein kinase JAK2 / 0.658
3i5z Z48Mitogen-activated protein kinase 1 2.7.11.24 0.654
3elj GS7Mitogen-activated protein kinase 8 2.7.11.24 0.652
1urw I1PCyclin-dependent kinase 2 2.7.11.22 0.651
4fko 20KCyclin-dependent kinase 2 2.7.11.22 0.651
4im2 BX7Serine/threonine-protein kinase TBK1 2.7.11.1 0.651
4brx KGWFocal adhesion kinase 1 2.7.10.2 0.650