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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2iw6 QQ2 Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2iw6 QQ2Cyclin-dependent kinase 2 2.7.11.22 0.999
3qtq X35Cyclin-dependent kinase 2 2.7.11.22 0.679
3rk9 09ZCyclin-dependent kinase 2 2.7.11.22 0.672
4ccb OFGALK tyrosine kinase receptor 2.7.10.1 0.672
3rk7 08ZCyclin-dependent kinase 2 2.7.11.22 0.671
3rjc 06ZCyclin-dependent kinase 2 2.7.11.22 0.669
4bgh 3I6Cyclin-dependent kinase 2 2.7.11.22 0.669
2bts U32Cyclin-dependent kinase 2 2.7.11.22 0.668
2x1n X1NCyclin-dependent kinase 2 2.7.11.22 0.663
3r8v Z62Cyclin-dependent kinase 2 2.7.11.22 0.663
3rni 21ZCyclin-dependent kinase 2 2.7.11.22 0.659
1vyw 292Cyclin-dependent kinase 2 2.7.11.22 0.658
3rk5 07ZCyclin-dependent kinase 2 2.7.11.22 0.656
4qmu SKESerine/threonine-protein kinase 24 2.7.11.1 0.656
2jko BIJFocal adhesion kinase 1 2.7.10.2 0.654
3o0g 3O0Cyclin-dependent-like kinase 5 2.7.11.1 0.653
4fki 09KCyclin-dependent kinase 2 2.7.11.22 0.653
4fkj 11KCyclin-dependent kinase 2 2.7.11.22 0.653