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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2itt AEE Epidermal growth factor receptor 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2itt AEEEpidermal growth factor receptor 2.7.10.1 0.955
2itp AEEEpidermal growth factor receptor 2.7.10.1 0.876
4jrv KJVEpidermal growth factor receptor 2.7.10.1 0.781
4jq8 KJ8Epidermal growth factor receptor 2.7.10.1 0.772
4e5i 0N9Polymerase acidic protein / 0.744
2itz IREEpidermal growth factor receptor 2.7.10.1 0.675
4c3f 7KWTyrosine-protein kinase Lck 2.7.10.2 0.675
2z7q ACPRibosomal protein S6 kinase alpha-1 2.7.11.1 0.660
4e5f 0N7Polymerase acidic protein / 0.660
4i22 IREEpidermal growth factor receptor 2.7.10.1 0.659
1bl6 SB6Mitogen-activated protein kinase 14 / 0.655
3hng 8STVascular endothelial growth factor receptor 1 2.7.10.1 0.652
2wou ZZFTGF-beta receptor type-1 2.7.11.30 0.651
2x9f X9FEphrin type-B receptor 4 2.7.10.1 0.651