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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2itp AEE Epidermal growth factor receptor 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2itp AEEEpidermal growth factor receptor 2.7.10.1 1.018
2itt AEEEpidermal growth factor receptor 2.7.10.1 0.876
4jq8 KJ8Epidermal growth factor receptor 2.7.10.1 0.808
4jr3 KJREpidermal growth factor receptor 2.7.10.1 0.789
4jrv KJVEpidermal growth factor receptor 2.7.10.1 0.785
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4c3f 7KWTyrosine-protein kinase Lck 2.7.10.2 0.679
4wkq IREEpidermal growth factor receptor 2.7.10.1 0.678
3zs5 SB2Mitogen-activated protein kinase 14 / 0.669
2vwz 7X6Ephrin type-B receptor 4 2.7.10.1 0.664
2itz IREEpidermal growth factor receptor 2.7.10.1 0.663
2vww 7X2Ephrin type-B receptor 4 2.7.10.1 0.663
4e5f 0N7Polymerase acidic protein / 0.660
2z7q ACPRibosomal protein S6 kinase alpha-1 2.7.11.1 0.659
4jq7 KJQEpidermal growth factor receptor 2.7.10.1 0.659