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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2is7 2CL Aldose reductase 1.1.1.21

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2is7 2CLAldose reductase 1.1.1.21 0.837
2ipw 2CLAldose reductase 1.1.1.21 0.752
3t42 3T4Aldose reductase 1.1.1.21 0.713
2pzn 393Aldose reductase 1.1.1.21 0.708
3m64 393Aldose reductase 1.1.1.21 0.706
2inz OHPAldose reductase 1.1.1.21 0.695
2ikj 393Aldose reductase 1.1.1.21 0.693
2pdq 47DAldose reductase 1.1.1.21 0.690
2iqd LPAAldose reductase 1.1.1.21 0.688
2pdj 393Aldose reductase 1.1.1.21 0.688
2pdu 393Aldose reductase 1.1.1.21 0.676
3u2c SUZAldose reductase 1.1.1.21 0.673
2nvc ITAAldose reductase 1.1.1.21 0.672
2pdc 393Aldose reductase 1.1.1.21 0.661
2pdx ZSTAldose reductase 1.1.1.21 0.656
1iei ZESAldose reductase 1.1.1.21 0.653