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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2ipw 2CL Aldose reductase 1.1.1.21

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2ipw 2CLAldose reductase 1.1.1.21 0.825
2is7 2CLAldose reductase 1.1.1.21 0.752
2pdl TOLAldose reductase 1.1.1.21 0.695
2dv0 ZSTAldose reductase 1.1.1.21 0.692
2fzd TOLAldose reductase 1.1.1.21 0.678
2ikh LITAldose reductase 1.1.1.21 0.677
2inz OHPAldose reductase 1.1.1.21 0.670
1frb ZSTAldose reductase-related protein 2 / 0.668
2nvc ITAAldose reductase 1.1.1.21 0.667
2pdm ZSTAldose reductase 1.1.1.21 0.661
2i17 LDTAldose reductase 1.1.1.21 0.656
1us0 LDTAldose reductase 1.1.1.21 0.655
2i16 LDTAldose reductase 1.1.1.21 0.655
2qxw LDTAldose reductase 1.1.1.21 0.655
2iqd LPAAldose reductase 1.1.1.21 0.652
3ghr LDTAldose reductase 1.1.1.21 0.651
3ghs LDTAldose reductase 1.1.1.21 0.651