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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2iht TPP N(2)-(2-carboxyethyl)arginine synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2iht TPPN(2)-(2-carboxyethyl)arginine synthase / 1.221
1upb TPPN(2)-(2-carboxyethyl)arginine synthase / 1.202
1upa TPPN(2)-(2-carboxyethyl)arginine synthase / 1.196
1upc TPPN(2)-(2-carboxyethyl)arginine synthase / 1.195
2ihv TPPN(2)-(2-carboxyethyl)arginine synthase / 1.121
2ihu TP9N(2)-(2-carboxyethyl)arginine synthase / 0.973
5ahk TPPAcetolactate synthase II, large subunit / 0.802
1ozh HE3Acetolactate synthase, catabolic 2.2.1.6 0.750
3d7k D7KBenzaldehyde lyase / 0.745
2ez9 TDKPyruvate oxidase 1.2.3.3 0.731
1y9d TPPPyruvate oxidase 1.2.3.3 0.726
2q5q TPWIndole-3-pyruvate decarboxylase 4.1.1.74 0.724
2c31 TZDOxalyl-CoA decarboxylase 4.1.1.8 0.717
1ovm TPPIndole-3-pyruvate decarboxylase 4.1.1.74 0.714
5esd TDP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.706
1jsc TPPAcetolactate synthase catalytic subunit, mitochondrial 2.2.1.6 0.704
2uz1 TPPBenzaldehyde lyase / 0.698
1pox TPPPyruvate oxidase 1.2.3.3 0.697
2ag0 TPPBenzaldehyde lyase / 0.696
1pow TPPPyruvate oxidase 1.2.3.3 0.691
2c3o TPPPyruvate synthase / 0.690
2c42 TPPPyruvate synthase / 0.689
2o1x TDP1-deoxy-D-xylulose-5-phosphate synthase 2.2.1.7 0.688
4cok TPPPyruvate decarboxylase / 0.682
4ju8 TZDBenzoylformate decarboxylase 4.1.1.7 0.680
2ji7 OXTOxalyl-CoA decarboxylase 4.1.1.8 0.679
2q5o TPWIndole-3-pyruvate decarboxylase 4.1.1.74 0.678
2ezt TDMPyruvate oxidase 1.2.3.3 0.677
4jub TPPBenzoylformate decarboxylase 4.1.1.7 0.677
1itz TPPTransketolase, chloroplastic 2.2.1.1 0.676
1umc TDP2-oxoisovalerate dehydrogenase subunit alpha 1.2.4.4 0.676
1umc TDP2-oxoisovalerate dehydrogenase subunit beta 1.2.4.4 0.676
2v3w TPPBenzoylformate decarboxylase 4.1.1.7 0.670
2qta TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.669
3ey9 TDPPyruvate dehydrogenase [ubiquinone] 1.2.5.1 0.667
2ji9 TPWOxalyl-CoA decarboxylase 4.1.1.8 0.665
2jib TPPOxalyl-CoA decarboxylase 4.1.1.8 0.665
4k9n TZDBenzoylformate decarboxylase 4.1.1.7 0.665
2vk8 TPPPyruvate decarboxylase isozyme 1 / 0.664
4gm0 TZDBenzoylformate decarboxylase 4.1.1.7 0.663
4mzx TZDBenzoylformate decarboxylase 4.1.1.7 0.661
2w93 TPPPyruvate decarboxylase isozyme 1 / 0.660
4gm4 TZDBenzoylformate decarboxylase 4.1.1.7 0.660
1kek HTLPyruvate synthase / 0.658
3dva TPWPyruvate dehydrogenase E1 component subunit alpha 1.2.4.1 0.658
3dva TPWPyruvate dehydrogenase E1 component subunit beta 1.2.4.1 0.658
4jd5 TZDBenzoylformate decarboxylase 4.1.1.7 0.658
5c4i TPPOxalate oxidoreductase subunit alpha / 0.658
5c4i TPPOxalate oxidoreductase subunit beta / 0.658
2ag1 TPPBenzaldehyde lyase / 0.657
1pyd TDPPyruvate decarboxylase isozyme 1 / 0.655
2uza HTLPyruvate synthase / 0.655
4juc TPPBenzoylformate decarboxylase 4.1.1.7 0.654
2j9f THV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 1.2.4.4 0.653
2j9f THV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial 1.2.4.4 0.653
3zhr TPPMultifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.652
4gm1 TZDBenzoylformate decarboxylase 4.1.1.7 0.652
1gpu THDTransketolase 1 2.2.1.1 0.651
2g25 TDKPyruvate dehydrogenase E1 component 1.2.4.1 0.651
2c3u 2TPPyruvate synthase / 0.650