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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2ghl LIB Mitogen-activated protein kinase 14

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2ghl LIBMitogen-activated protein kinase 14 / 1.096
2ghm LICMitogen-activated protein kinase 14 / 0.855
4lop SB4Mitogen-activated protein kinase 14 / 0.744
4loo SB4Mitogen-activated protein kinase 14 / 0.715
3fkn FKNMitogen-activated protein kinase 14 / 0.705
1ywr LI9Mitogen-activated protein kinase 14 / 0.701
4f9w LM4Mitogen-activated protein kinase 14 / 0.701
1bl6 SB6Mitogen-activated protein kinase 14 / 0.694
3fln 3FNMitogen-activated protein kinase 14 / 0.686
3gc7 B45Mitogen-activated protein kinase 14 / 0.684
3iw5 DF3Mitogen-activated protein kinase 14 / 0.682
3fl4 FL4Mitogen-activated protein kinase 14 / 0.672
1zzl TZYMitogen-activated protein kinase 14 / 0.671
3flw FLWMitogen-activated protein kinase 14 / 0.671
4ewq MWLMitogen-activated protein kinase 14 / 0.670
4aoj V4ZHigh affinity nerve growth factor receptor 2.7.10.1 0.668
4loq SB4Mitogen-activated protein kinase 14 / 0.667
3fls FLSMitogen-activated protein kinase 14 / 0.666
3hl7 I47Mitogen-activated protein kinase 14 / 0.665
3hvc GG5Mitogen-activated protein kinase 14 / 0.662
1pme SB2Mitogen-activated protein kinase 1 2.7.11.24 0.659
3c5u P41Mitogen-activated protein kinase 14 / 0.659
1bmk SB5Mitogen-activated protein kinase 14 / 0.658
3fmj FMJMitogen-activated protein kinase 14 / 0.656
3gcp SB2Mitogen-activated protein kinase 14 / 0.652
4jq7 KJQEpidermal growth factor receptor 2.7.10.1 0.652
1yw2 PGJMitogen-activated protein kinase 14 / 0.650