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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2fzd TOL Aldose reductase 1.1.1.21

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2fzd TOLAldose reductase 1.1.1.21 1.048
2pdl TOLAldose reductase 1.1.1.21 0.822
1ah3 TOLAldose reductase 1.1.1.21 0.789
1zua TOLAldo-keto reductase family 1 member B10 1.1.1 0.788
2fzb TOLAldose reductase 1.1.1.21 0.731
2pdj 393Aldose reductase 1.1.1.21 0.698
1us0 LDTAldose reductase 1.1.1.21 0.678
2i16 LDTAldose reductase 1.1.1.21 0.678
2ipw 2CLAldose reductase 1.1.1.21 0.678
3ghr LDTAldose reductase 1.1.1.21 0.678
3ghs LDTAldose reductase 1.1.1.21 0.678
3m4h 388Aldose reductase 1.1.1.21 0.678
3ghu LDTAldose reductase 1.1.1.21 0.670
2i17 LDTAldose reductase 1.1.1.21 0.669
2iki 388Aldose reductase 1.1.1.21 0.669
2ikh LITAldose reductase 1.1.1.21 0.668
3m64 393Aldose reductase 1.1.1.21 0.667
2ikj 393Aldose reductase 1.1.1.21 0.663
3lbo LDTAldose reductase 1.1.1.21 0.653