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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2fq6 P3F Cystathionine beta-lyase MetC 4.4.1.8

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2fq6 P3FCystathionine beta-lyase MetC 4.4.1.8 1.182
2gqn BLPCystathionine beta-lyase MetC 4.4.1.8 1.017
1cl2 PPGCystathionine beta-lyase MetC 4.4.1.8 0.921
4itx IN5Cystathionine beta-lyase MetC 4.4.1.8 0.901
2bwp PLG5-aminolevulinate synthase 2.3.1.37 0.706
1akc PPEAspartate aminotransferase, mitochondrial 2.6.1.1 0.701
1oxo IK2Aspartate aminotransferase, mitochondrial 2.6.1.1 0.696
1akb PPDAspartate aminotransferase, mitochondrial 2.6.1.1 0.684
4eb5 PLPCysteine desulfurase IscS 2 / 0.683
1map KETAspartate aminotransferase, mitochondrial 2.6.1.1 0.681
4eb7 PLPCysteine desulfurase IscS 2 / 0.678
4wxg 2BOSerine hydroxymethyltransferase / 0.674
1arh PPDAspartate aminotransferase 2.6.1.1 0.672
4oma LCSMethionine gamma-lyase / 0.672
3zrr PXGSerine-pyruvate aminotransferase (AgxT) / 0.669
1ivr CBAAspartate aminotransferase, mitochondrial 2.6.1.1 0.667
1cq8 PY6Aspartate aminotransferase 2.6.1.1 0.662
3tqx PLP2-amino-3-ketobutyrate coenzyme A ligase / 0.660
4obu PLPPyridoxal-dependent decarboxylase domain protein / 0.659
4wlj IK2Kynurenine--oxoglutarate transaminase 1 2.6.1.7 0.659
1ahg TYR_PLPAspartate aminotransferase 2.6.1.1 0.657
1arg PPDAspartate aminotransferase 2.6.1.1 0.657
4d9f DCSD-cysteine desulfhydrase / 0.657
1x28 PGUAspartate aminotransferase 2.6.1.1 0.655
4adc PLPSuccinylornithine transaminase 2.6.1.81 0.651