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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2erz HFS cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2erz HFScAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.948
2etk HFSRho-associated protein kinase 1 2.7.11.1 0.717
1nvq UCNSerine/threonine-protein kinase Chk1 2.7.11.1 0.696
3a62 STURibosomal protein S6 kinase beta-1 2.7.11.1 0.688
1okz UCN3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.681
3uli 1N3Cyclin-dependent kinase 2 2.7.11.22 0.680
1nvr STUSerine/threonine-protein kinase Chk1 2.7.11.1 0.675
2dq7 STUTyrosine-protein kinase Fyn 2.7.10.2 0.669
1yvj 4STTyrosine-protein kinase JAK3 2.7.10.2 0.664
4f08 1RSTyrosine-protein kinase JAK2 / 0.663
4ivc 1J6Tyrosine-protein kinase JAK1 / 0.662
3cbl STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.658
3qd4 3Q63-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.658
4c58 824Cyclin-G-associated kinase 2.7.11.1 0.658
2c1b CQPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.657
3sc1 3S13-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.656
2j0j 4STFocal adhesion kinase 1 2.7.10.2 0.655
4e6q 0NVTyrosine-protein kinase JAK2 / 0.655
1stc STUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.653
2nry STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.652
3cqw CQWRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.652
1jpa ANPEphrin type-B receptor 2 2.7.10.1 0.650