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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2dvm NAD 439aa long hypothetical malate oxidoreductase (NAD) [malic enzyme]

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2dvm NAD439aa long hypothetical malate oxidoreductase (NAD) [malic enzyme] / 0.972
2hjr APRMalate dehydrogenase, adjacent gene encodes predicted lactate dehydrogenase / 0.744
4ros APRMalate dehydrogenase / 0.738
1pzh NADLactate dehydrogenase / 0.721
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.719
4wlu NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.719
1qr6 NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.713
2dfd NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.704
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.700
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.698
4wlv NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.697
2a94 AP0L-lactate dehydrogenase 1.1.1.27 0.694
2o4c NADErythronate-4-phosphate dehydrogenase / 0.692
2a92 NAIL-lactate dehydrogenase / 0.689
2x0i NAIMalate dehydrogenase / 0.688
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.686
4nd2 A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.685
2fn7 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.684
1llq NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.679
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.678
4j4b NAIUncharacterized protein / 0.676
3wv7 ADPHmd co-occurring protein HcgE / 0.674
1f0y NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.672
1t2c NAIL-lactate dehydrogenase 1.1.1.27 0.671
3dmt NADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal 1.2.1.12 0.670
1ib6 NADMalate dehydrogenase / 0.668
1o6z NADMalate dehydrogenase / 0.668
2nad NADFormate dehydrogenase / 0.668
2gsd NADFormate dehydrogenase / 0.666
3gvi ADPMalate dehydrogenase / 0.666
1hku NADC-terminal-binding protein 1 1.1.1 0.665
1b3r NADAdenosylhomocysteinase 3.3.1.1 0.664
2ixa NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.664
4kug NAD3-hydroxybutyryl-CoA dehydrogenase / 0.664
1i2b NADUDP-sulfoquinovose synthase, chloroplastic 3.13.1.1 0.663
1f17 NAIHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.659
3ggo NAIPrephenate dehydrogenase / 0.659
3d64 NADAdenosylhomocysteinase / 0.658
1m75 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.657
3tnl NADShikimate dehydrogenase (NADP(+)) / 0.657
5ees NAP4-hydroxy-tetrahydrodipicolinate reductase / 0.657
4xgi NADGlutamate dehydrogenase / 0.656
4jnk NAIL-lactate dehydrogenase A chain 1.1.1.27 0.655
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.655
1ie3 NADMalate dehydrogenase / 0.654
3keo NADRedox-sensing transcriptional repressor Rex / 0.654
1uxj NADMalate dehydrogenase / 0.653
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.652
3ec7 NADInositol 2-dehydrogenase / 0.651
5mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.651
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.650