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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2cy0 NAP Shikimate dehydrogenase (NADP(+))

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2cy0 NAPShikimate dehydrogenase (NADP(+)) / 1.198
2ev9 NAPShikimate dehydrogenase (NADP(+)) / 0.955
1nyt NAPShikimate dehydrogenase (NADP(+)) / 0.831
2hk9 NAPShikimate dehydrogenase (NADP(+)) / 0.744
3tnl NADShikimate dehydrogenase (NADP(+)) / 0.737
3t4e NADQuinate/shikimate dehydrogenase / 0.712
4k28 NADShikimate dehydrogenase family protein / 0.692
1npd NADQuinate/shikimate dehydrogenase / 0.691
3phi NDPShikimate dehydrogenase (NADP(+)) / 0.688
3zhb NAPPutative dehydrogenase / 0.686
1vi2 NADQuinate/shikimate dehydrogenase / 0.684
1nvt NAPShikimate dehydrogenase (NADP(+)) / 0.671
1q0q NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase 1.1.1.267 0.670
3toz NADShikimate dehydrogenase (NADP(+)) / 0.670
4hp8 NAP2-deoxy-D-gluconate 3-dehydrogenase / 0.670
4y1b NAPAntE / 0.670
4bv9 NDPKetimine reductase mu-crystallin 1.5.1.25 0.666
3pdu NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.664
1wp4 NDP3-hydroxyisobutyrate dehydrogenase / 0.663
5dp2 NAPCurF / 0.661
2iyp A2P6-phosphogluconate dehydrogenase, decarboxylating 1.1.1.44 0.657
4y0k NAPAntE / 0.652
2cvz NDP3-hydroxyisobutyrate dehydrogenase / 0.650