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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2cvy TTP Ribonucleoside-diphosphate reductase large chain 1 1.17.4.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2cvy TTPRibonucleoside-diphosphate reductase large chain 1 1.17.4.1 0.996
3k8t DGTRibonucleoside-diphosphate reductase large chain 1 1.17.4.1 0.805
3s8a DGTRibonucleoside-diphosphate reductase large chain 1 1.17.4.1 0.805
2cvx DGTRibonucleoside-diphosphate reductase large chain 1 1.17.4.1 0.803
2cvv ANPRibonucleoside-diphosphate reductase large chain 1 1.17.4.1 0.786
2cvu ANPRibonucleoside-diphosphate reductase large chain 1 1.17.4.1 0.783
3tb9 ANPRibonucleoside-diphosphate reductase large chain 1 1.17.4.1 0.771
2cvw TTPRibonucleoside-diphosphate reductase large chain 1 1.17.4.1 0.770
1xje TTPVitamin B12-dependent ribonucleotide reductase / 0.746
1xjg DTPVitamin B12-dependent ribonucleotide reductase / 0.730
3o0q TTPVitamin B12-dependent ribonucleotide reductase / 0.725
1peq TTPRibonucleoside-diphosphate reductase 2 subunit alpha 1.17.4.1 0.724
2eud ANPRibonucleoside-diphosphate reductase large chain 1 1.17.4.1 0.715
3s87 DGTRibonucleoside-diphosphate reductase large chain 1 1.17.4.1 0.715
3rsr N5PRibonucleoside-diphosphate reductase large chain 1 1.17.4.1 0.709
1xjk DGTVitamin B12-dependent ribonucleotide reductase / 0.701
3o0n TTPVitamin B12-dependent ribonucleotide reductase / 0.693
1xjj DGTVitamin B12-dependent ribonucleotide reductase / 0.692
3o0o TTPVitamin B12-dependent ribonucleotide reductase / 0.683
1u5a BIKL-lactate dehydrogenase 1.1.1.27 0.658
1aj2 2PHDihydropteroate synthase / 0.654
1peo DCPRibonucleoside-diphosphate reductase 2 subunit alpha 1.17.4.1 0.653
3s8c ANPRibonucleoside-diphosphate reductase large chain 1 1.17.4.1 0.652