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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2cd2 FOL Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2cd2 FOLDihydrofolate reductase 1.5.1.3 1.057
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.861
4m6k FOLDihydrofolate reductase 1.5.1.3 0.842
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.831
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.829
4x5g FOLDihydrofolate reductase 1.5.1.3 0.818
4x5f FOLDihydrofolate reductase 1.5.1.3 0.815
4keb FOLDihydrofolate reductase 1.5.1.3 0.810
1dyi FOLDihydrofolate reductase 1.5.1.3 0.803
1hfr MOTDihydrofolate reductase 1.5.1.3 0.803
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.802
4kfj FOLDihydrofolate reductase 1.5.1.3 0.802
1dyh DZFDihydrofolate reductase 1.5.1.3 0.800
2w3m FOLDihydrofolate reductase 1.5.1.3 0.799
1e26 GPBDihydrofolate reductase 1.5.1.3 0.797
7dfr FOLDihydrofolate reductase 1.5.1.3 0.797
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.796
2d0k FOLDihydrofolate reductase 1.5.1.3 0.792
4x5h FOLDihydrofolate reductase 1.5.1.3 0.789
1dhf FOLDihydrofolate reductase 1.5.1.3 0.781
4x5i FOLDihydrofolate reductase 1.5.1.3 0.781
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.777
1dhi MTXDihydrofolate reductase 1.5.1.3 0.775
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.772
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.770
2zza FOLDihydrofolate reductase / 0.769
1df7 MTXDihydrofolate reductase 1.5.1.3 0.767
4kjj FOLDihydrofolate reductase 1.5.1.3 0.766
1hfq MOTDihydrofolate reductase 1.5.1.3 0.762
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.762
2qk8 MTXDihydrofolate reductase / 0.760
4i13 FOLDihydrofolate reductase 1.5.1.3 0.760
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.758
3tq9 MTXDihydrofolate reductase / 0.755
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.754
4m6l 21VDihydrofolate reductase 1.5.1.3 0.754
3eig MTXDihydrofolate reductase 1.5.1.3 0.753
1dre MTXDihydrofolate reductase 1.5.1.3 0.750
4p66 MTXDihydrofolate reductase / 0.750
1dra MTXDihydrofolate reductase 1.5.1.3 0.749
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.749
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.749
1u70 MTXDihydrofolate reductase 1.5.1.3 0.749
2drc MTXDihydrofolate reductase 1.5.1.3 0.748
1drf FOLDihydrofolate reductase 1.5.1.3 0.744
1dls MTXDihydrofolate reductase 1.5.1.3 0.741
1drb MTXDihydrofolate reductase 1.5.1.3 0.739
1re7 FOLDihydrofolate reductase 1.5.1.3 0.739
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.738
3dau MTXDihydrofolate reductase 1.5.1.3 0.738
1dyj DDFDihydrofolate reductase 1.5.1.3 0.736
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.736
4qi9 MTXDihydrofolate reductase / 0.736
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.734
3tqb FOLDihydrofolate reductase / 0.733
4i1n FOLDihydrofolate reductase 1.5.1.3 0.733
1jom FFODihydrofolate reductase 1.5.1.3 0.727
3dfr MTXDihydrofolate reductase 1.5.1.3 0.722
5hi6 MTXDihydrofolate reductase / 0.719
3och 2MXDihydrofolate reductase 1.5.1.3 0.718
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.717
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.716
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.713
1u72 MTXDihydrofolate reductase 1.5.1.3 0.712
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.712
1tdr MTXDihydrofolate reductase 1.5.1.3 0.710
1hfp MOTDihydrofolate reductase 1.5.1.3 0.708
4dfr MTXDihydrofolate reductase 1.5.1.3 0.707
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.705
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.703
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.703
3drc MTXDihydrofolate reductase 1.5.1.3 0.702
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.702
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.701
5ccc DDFDihydrofolate reductase 1.5.1.3 0.701
1ohj COPDihydrofolate reductase 1.5.1.3 0.700
4fhb FOLDihydrofolate reductase 1.5.1.3 0.700
2dhf DZFDihydrofolate reductase 1.5.1.3 0.698
1jol FFODihydrofolate reductase 1.5.1.3 0.690
4p68 MTXDihydrofolate reductase / 0.688
1dhj MTXDihydrofolate reductase 1.5.1.3 0.678
3td8 D2RDihydrofolate reductase 1.5.1.3 0.673
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.672
2ay8 4TBAromatic-amino-acid aminotransferase 2.6.1.57 0.664
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.664
3ia4 MTXDihydrofolate reductase / 0.661
1rb2 FOLDihydrofolate reductase 1.5.1.3 0.654
1asc NPLAspartate aminotransferase 2.6.1.1 0.653
1ohk COPDihydrofolate reductase 1.5.1.3 0.652
1qzf FOLBifunctional dihydrofolate reductase-thymidylate synthase / 0.652
1zha PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.651