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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2c5y MTW Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2c5y MTWCyclin-dependent kinase 2 2.7.11.22 0.972
4ek8 16KCyclin-dependent kinase 2 2.7.11.22 0.761
4fko 20KCyclin-dependent kinase 2 2.7.11.22 0.716
3sw4 18KCyclin-dependent kinase 2 2.7.11.22 0.681
1pxm CK5Cyclin-dependent kinase 2 2.7.11.22 0.673
2xnb Y8LCyclin-dependent kinase 2 2.7.11.22 0.667
1urw I1PCyclin-dependent kinase 2 2.7.11.22 0.661
1oir HDYCyclin-dependent kinase 2 2.7.11.22 0.660
2xmy CDKCyclin-dependent kinase 2 2.7.11.22 0.659
3uo5 0BXAurora kinase A 2.7.11.1 0.659
4dea NHIAurora kinase A 2.7.11.1 0.658
4aot GW8Serine/threonine-protein kinase 10 2.7.11.1 0.657
2vv9 IM9Cyclin-dependent kinase 2 2.7.11.22 0.654
3emg 685Tyrosine-protein kinase SYK 2.7.10.2 0.650