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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2c4g 514 Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2c4g 514Cyclin-dependent kinase 2 2.7.11.22 0.873
2bmc MPYAurora kinase A 2.7.11.1 0.671
2wpa 889Cyclin-dependent kinase 2 2.7.11.22 0.662
2owb 626Serine/threonine-protein kinase PLK1 2.7.11.21 0.660
3amb VX6cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.657
2vtp LZ9Cyclin-dependent kinase 2 2.7.11.22 0.655
4qo9 627Serine/threonine-protein kinase 24 2.7.11.1 0.655
1vyz N5BCyclin-dependent kinase 2 2.7.11.22 0.654
2vto LZ8Cyclin-dependent kinase 2 2.7.11.22 0.653
2j50 627Aurora kinase A 2.7.11.1 0.652