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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2bwp PLG 5-aminolevulinate synthase 2.3.1.37

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2bwp PLG5-aminolevulinate synthase 2.3.1.37 1.009
3tqx PLP2-amino-3-ketobutyrate coenzyme A ligase / 0.727
2gqn BLPCystathionine beta-lyase MetC 4.4.1.8 0.726
2fq6 P3FCystathionine beta-lyase MetC 4.4.1.8 0.706
1u08 PLPMethionine aminotransferase / 0.703
1akb PPDAspartate aminotransferase, mitochondrial 2.6.1.1 0.702
4eb5 PLPCysteine desulfurase IscS 2 / 0.697
1x28 PGUAspartate aminotransferase 2.6.1.1 0.687
4wlj IK2Kynurenine--oxoglutarate transaminase 1 2.6.1.7 0.681
4jey PLPAcetylornithine/succinyldiaminopimelate aminotransferase 2.6.1.11 0.679
1arh PPDAspartate aminotransferase 2.6.1.1 0.675
4zwm PLPOrnithine aminotransferase, mitochondrial, putative / 0.675
1cl2 PPGCystathionine beta-lyase MetC 4.4.1.8 0.672
3ele PLPAminotransferase / 0.665
1mlz PLPAdenosylmethionine-8-amino-7-oxononanoate aminotransferase 2.6.1.62 0.663
4eb7 PLPCysteine desulfurase IscS 2 / 0.663
1map KETAspartate aminotransferase, mitochondrial 2.6.1.1 0.662
4aoa IK2Beta-phenylalanine transaminase 2.6.1 0.661
1oxo IK2Aspartate aminotransferase, mitochondrial 2.6.1.1 0.655
4adc PLPSuccinylornithine transaminase 2.6.1.81 0.655
1akc PPEAspartate aminotransferase, mitochondrial 2.6.1.1 0.653
4ba5 PXGProbable aminotransferase / 0.650