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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2bu8 ADP [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2bu8 ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.877
2bu2 ATP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.792
3d2r ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.744
2zkj ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.734
1z5c ADPType 2 DNA topoisomerase 6 subunit B / 0.711
4prv ADPDNA gyrase subunit B / 0.711
1th8 ADPAnti-sigma F factor / 0.708
3crl ANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.701
1z59 ADPType 2 DNA topoisomerase 6 subunit B / 0.688
2zdy ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.678
2e0a ANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.677
4prx ADPDNA gyrase subunit B / 0.673
4bix ADPSensor histidine kinase CpxA / 0.671
1pvg ANPDNA topoisomerase 2 5.99.1.3 0.670
1zxm ANPDNA topoisomerase 2-alpha 5.99.1.3 0.667
1id0 ANPSensor protein PhoQ 2.7.13.3 0.664
1gjv AGS[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial 2.7.11.4 0.663
2ior ADPChaperone protein HtpG / 0.662
1mx0 ANPType 2 DNA topoisomerase 6 subunit B / 0.658
1z5a ADPType 2 DNA topoisomerase 6 subunit B / 0.656
5a88 ADPRiboflavin biosynthesis protein RibF 2.7.1.26 0.656
2c2a ADPSensor histidine kinase / 0.654
4ipe ANPTNF receptor-associated protein 1 / 0.652
1y4s ADPChaperone protein HtpG / 0.651
1zxn ADPDNA topoisomerase 2-alpha 5.99.1.3 0.651
1i5a ACPChemotaxis protein CheA 2.7.13.3 0.650