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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2b1z 17M Estrogen receptor

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2b1z 17MEstrogen receptor / 1.097
5dxg ESTEstrogen receptor / 1.028
4pxm ESTEstrogen receptor / 1.020
3uud ESTEstrogen receptor / 1.018
3l03 4OHEstrogen receptor / 1.001
2yja ESTEstrogen receptor / 1.000
2p15 EZTEstrogen receptor / 0.972
5hyr ESTEstrogen receptor / 0.955
2qgt EEDEstrogen receptor / 0.934
1gwr ESTEstrogen receptor / 0.931
3q95 ESLEstrogen receptor / 0.929
3oll ESTEstrogen receptor beta / 0.927
5dx3 ESTEstrogen receptor / 0.905
4j26 ESTEstrogen receptor beta / 0.882
4j24 ESTEstrogen receptor beta / 0.875
2yat EEUEstrogen receptor / 0.874
2j7x ESTEstrogen receptor beta / 0.870
2ocf ESTEstrogen receptor / 0.825
1g50 ESTEstrogen receptor / 0.800
4pp6 STLEstrogen receptor / 0.733
1x7e 244Estrogen receptor / 0.728
4iui 1GQEstrogen receptor / 0.715
2w8y 486Progesterone receptor / 0.713
3ols ESTEstrogen receptor beta / 0.704
2g5o DRQEstrogen receptor / 0.694
1lho AOMSex hormone-binding globulin / 0.677
2aa5 STRMineralocorticoid receptor / 0.675
1zhy CLROxysterol-binding protein homolog 4 / 0.668
4e5f 0N7Polymerase acidic protein / 0.665
1qjg EQUSteroid Delta-isomerase 5.3.3.1 0.664
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.660
3myt EQUSteroid Delta-isomerase 5.3.3.1 0.660
4nky 3QZSteroid 17-alpha-hydroxylase/17,20 lyase / 0.659
1x7j GENEstrogen receptor beta / 0.658
2hrc CHDFerrochelatase, mitochondrial 4.99.1.1 0.658
3iw1 ASDSteroid C26-monooxygenase 1.14.13.141 0.658
3s79 ASDAromatase 1.14.14.14 0.653
4at2 ASDPossible succinate dehydrogenase / 0.653
3eqm ASDAromatase 1.14.14.14 0.651
1i5r HYCEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.650