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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1zw5 ZOL Farnesyl pyrophosphate synthase 2.5.1.10

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1zw5 ZOLFarnesyl pyrophosphate synthase 2.5.1.10 0.989
4nke RISFarnesyl pyrophosphate synthase 2.5.1.10 0.887
3ez3 ZOLFarnesyl pyrophosphate synthase, putative / 0.877
3ldw ZOLFarnesyl pyrophosphate synthase, putative / 0.859
4kqs RISFarnesyl pyrophosphate synthase 2.5.1.10 0.834
4h5c YS4Farnesyl pyrophosphate synthase 2.5.1.10 0.821
4h5d YS4Farnesyl pyrophosphate synthase 2.5.1.10 0.820
2f94 BFQFarnesyl pyrophosphate synthase 2.5.1.10 0.815
4lfv YS4Farnesyl pyrophosphate synthase 2.5.1.10 0.813
4h5e YS4Farnesyl pyrophosphate synthase 2.5.1.10 0.802
3icz PB6Farnesyl pyrophosphate synthase / 0.799
3rye UNRFarnesyl pyrophosphate synthase 2.5.1.10 0.798
1rqj RISFarnesyl diphosphate synthase 2.5.1.10 0.796
2e95 B75Geranylgeranyl pyrophosphate synthase / 0.790
4q23 RISFarnesyl pyrophosphate synthase 2.5.1.10 0.785
3egt 722Farnesyl pyrophosphate synthase / 0.783
4dem YS4Farnesyl pyrophosphate synthase 2.5.1.10 0.782
4dwb 0M7Farnesyl pyrophosphate synthase / 0.775
4ga3 4GAFarnesyl pyrophosphate synthase 2.5.1.10 0.767
5erm 210Fusicoccadiene synthase 4.2.3.43 0.762
2e91 ZOLGeranylgeranyl pyrophosphate synthase / 0.760
3dyh 721Farnesyl pyrophosphate synthase / 0.757
4l2x YL2Farnesyl pyrophosphate synthase 2.5.1.10 0.754
1yv5 RISFarnesyl pyrophosphate synthase 2.5.1.10 0.748
2z4z SC0Geranylgeranyl pyrophosphate synthase / 0.726
1yq7 RISFarnesyl pyrophosphate synthase 2.5.1.10 0.720
4dxj 0M9Farnesyl pyrophosphate synthase / 0.713
2o1o RISPutative farnesyl pyrophosphate synthase / 0.706
2zev B71Geranylgeranyl pyrophosphate synthase / 0.706
4mrt COA4'-phosphopantetheinyl transferase sfp 2.7.8 0.704
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.700
4qfz TTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.681
4brd ANPEctonucleoside triphosphate diphosphohydrolase I / 0.677
2z52 H23Geranylgeranyl pyrophosphate synthase / 0.675
2zcq B65Dehydrosqualene synthase / 0.675
5ero 210Fusicoccadiene synthase 2.5.1.29 0.675
1svm ATPLarge T antigen 3.6.4 0.671
3kmw ATPIntegrin-linked protein kinase 2.7.11.1 0.670
4kh0 ATPAspartate carbamoyltransferase regulatory chain {ECO:0000256|HAMAP-Rule:MF_00002} / 0.665
2gqr ADPPhosphoribosylaminoimidazole-succinocarboxamide synthase 6.3.2.6 0.664
3ffk ATPActin, alpha skeletal muscle / 0.663
2hgs ADPGlutathione synthetase 6.3.2.3 0.662
2z4w 749Geranylgeranyl pyrophosphate synthase / 0.662
3mhy ATPNitrogen regulatory protein P-II 1 / 0.661
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.660
1n2e APCPantothenate synthetase 6.3.2.1 0.658
1rae CTPAspartate carbamoyltransferase regulatory chain / 0.658
5flj QUEQuercetinase QueD / 0.658
3mle ADPATP-dependent dethiobiotin synthetase BioD 6.3.3.3 0.657
2io7 ANPBifunctional glutathionylspermidine synthetase/amidase / 0.656
1e4y AP5Adenylate kinase / 0.655
1w78 PD8Dihydrofolate synthase/folylpolyglutamate synthase 6.3.2.12 0.655
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.654
2yeg XQGHeat shock protein HSP 90-alpha / 0.654
4a28 ADPKinesin-like protein KIF11 / 0.654
4eht ADP2-hydroxyisocaproyl-CoA dehydratase activator / 0.654
2vcz VC3Hematopoietic prostaglandin D synthase / 0.653
2ywv ADPPhosphoribosylaminoimidazole-succinocarboxamide synthase / 0.653
3ryw K9HFarnesyl pyrophosphate synthase, putative / 0.653
4qfy DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.653
2jlr ANPGenome polyprotein 3.4.21.91 0.652
3qft NAPNADPH--cytochrome P450 reductase / 0.652
3q5d GDPAtlastin-1 3.6.5 0.651
3qfs NAPNADPH--cytochrome P450 reductase / 0.651
4brg GNPEctonucleoside triphosphate diphosphohydrolase I / 0.651
3c4x ATPRhodopsin kinase / 0.650
4guk P2GNeuronal calcium sensor 1 / 0.650
4to0 DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.650
4to2 DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.650