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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1z89 62P Aldose reductase 1.1.1.21

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1z89 62PAldose reductase 1.1.1.21 0.918
3lql LDTAldose reductase 1.1.1.21 0.696
2ikj 393Aldose reductase 1.1.1.21 0.692
3m4h 388Aldose reductase 1.1.1.21 0.689
3lbo LDTAldose reductase 1.1.1.21 0.681
3ld5 LDTAldose reductase 1.1.1.21 0.681
3ght LDTAldose reductase 1.1.1.21 0.680
3ghu LDTAldose reductase 1.1.1.21 0.680
3m64 393Aldose reductase 1.1.1.21 0.680
3lz5 LDTAldose reductase 1.1.1.21 0.677
2iki 388Aldose reductase 1.1.1.21 0.676
2pzn 393Aldose reductase 1.1.1.21 0.676
3mc5 393Aldose reductase 1.1.1.21 0.675
4yu1 53NAldose reductase 1.1.1.21 0.667
4gca 2X9Aldose reductase 1.1.1.21 0.665
3ghs LDTAldose reductase 1.1.1.21 0.660
3ghr LDTAldose reductase 1.1.1.21 0.659
2fz9 ZSTAldose reductase 1.1.1.21 0.656
2pdg 47DAldose reductase 1.1.1.21 0.656
2pdj 393Aldose reductase 1.1.1.21 0.651
2pdf ZSTAldose reductase 1.1.1.21 0.650