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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1yon A2R 2-dehydropantoate 2-reductase 1.1.1.169

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1yon A2R2-dehydropantoate 2-reductase 1.1.1.169 1.125
1yjq NAP2-dehydropantoate 2-reductase 1.1.1.169 0.756
3hwr NDP2-dehydropantoate 2-reductase / 0.715
2x0i NAIMalate dehydrogenase / 0.686
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.683
4oaq NDPR-specific carbonyl reductase / 0.678
3pdu NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.671
4pxz CLRP2Y purinoceptor 12 / 0.671
2fn7 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.667
1yqd NAPSinapyl alcohol dehydrogenase / 0.665
3x2f NAIAdenosylhomocysteinase / 0.664
5hws NAP2-dehydropantoate 2-reductase / 0.663
3ulk NDPKetol-acid reductoisomerase (NADP(+)) / 0.661
1n1e NDEGlycerol-3-phosphate dehydrogenase [NAD(+)], glycosomal 1.1.1.8 0.657
4xgi NADGlutamate dehydrogenase / 0.657
1c1d NAIPhenylalanine dehydrogenase / 0.655
1cf2 NAPGlyceraldehyde-3-phosphate dehydrogenase / 0.655
2vhz NAIAlanine dehydrogenase 1.4.1.1 0.655
4lis NADUDP-glucose 4-epimerase (Eurofung) / 0.654
1pj2 NAINAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.653
1kph SAHCyclopropane mycolic acid synthase 1 2.1.1.79 0.652
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.652