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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1tkb N1T Transketolase 1 2.2.1.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1tkb N1TTransketolase 1 2.2.1.1 1.187
1ngs TPPTransketolase 1 2.2.1.1 0.941
3upt TPPTransketolase / 0.908
1trk TPPTransketolase 1 2.2.1.1 0.891
1gpu THDTransketolase 1 2.2.1.1 0.872
1tka N3TTransketolase 1 2.2.1.1 0.872
4c7x TPPTransketolase / 0.851
3m6l TPPTransketolase / 0.835
2r5n TPPTransketolase 1 / 0.834
1ay0 TPPTransketolase 1 2.2.1.1 0.826
1itz TPPTransketolase, chloroplastic 2.2.1.1 0.820
1tkc M6TTransketolase 1 2.2.1.1 0.812
2r8p T6FTransketolase 1 / 0.809
3rim TPPTransketolase 2.2.1.1 0.777
3m34 TPPTransketolase / 0.770
2g25 TDKPyruvate dehydrogenase E1 component 1.2.4.1 0.768
2r8o T5XTransketolase 1 / 0.768
3m7i TPPTransketolase / 0.747
2j9f THV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 1.2.4.4 0.712
2j9f THV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial 1.2.4.4 0.712
1ols TDP2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 1.2.4.4 0.705
3dv0 TPWPyruvate dehydrogenase E1 component subunit alpha 1.2.4.1 0.696
3dv0 TPWPyruvate dehydrogenase E1 component subunit beta 1.2.4.1 0.696
2jla TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.688
4mpr TPPBenzoylformate decarboxylase 4.1.1.7 0.687
4ju9 TZDBenzoylformate decarboxylase 4.1.1.7 0.686
4k9p TPPBenzoylformate decarboxylase 4.1.1.7 0.686
4qel TZDBenzoylformate decarboxylase 4.1.1.7 0.686
1bfd TPPBenzoylformate decarboxylase 4.1.1.7 0.684
1y9d TPPPyruvate oxidase 1.2.3.3 0.682
4ju8 TZDBenzoylformate decarboxylase 4.1.1.7 0.681
2ez9 TDKPyruvate oxidase 1.2.3.3 0.678
2ezt TDMPyruvate oxidase 1.2.3.3 0.675
4k9o TPPBenzoylformate decarboxylase 4.1.1.7 0.675
1w88 TDPPyruvate dehydrogenase E1 component subunit alpha 1.2.4.1 0.672
1w88 TDPPyruvate dehydrogenase E1 component subunit beta 1.2.4.1 0.672
4jub TPPBenzoylformate decarboxylase 4.1.1.7 0.670
4mq5 TPPBenzoylformate decarboxylase 4.1.1.7 0.669
2o1s TDP1-deoxy-D-xylulose-5-phosphate synthase 2.2.1.7 0.666
1l8a TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.663
4k9n TZDBenzoylformate decarboxylase 4.1.1.7 0.661
5ahk TPPAcetolactate synthase II, large subunit / 0.660
2fwn TDPBenzoylformate decarboxylase 4.1.1.7 0.658
4juf TPPBenzoylformate decarboxylase 4.1.1.7 0.658
4mpp TZDBenzoylformate decarboxylase 4.1.1.7 0.655
2vk8 TPPPyruvate decarboxylase isozyme 1 / 0.653
1po7 TZDBenzoylformate decarboxylase 4.1.1.7 0.652
4jd5 TZDBenzoylformate decarboxylase 4.1.1.7 0.650