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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1t8x PEP 2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1t8x PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.870
1zha PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.863
1zji 2PG2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.756
2nx3 PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.752
5aq1 NDPGlucose-6-phosphate 1-dehydrogenase / 0.672
1kfl PEPPhospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive 2.5.1.54 0.664
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.662
4qvh COAPhosphopantetheinyl transferase PptT (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrier protein]pantetheinephosphotransferase) / 0.661
4dc1 NDPPutative ketoacyl reductase 1.3.1 0.660
3ai2 NDPNADPH-sorbose reductase / 0.658
4to4 DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.657
1vhn FMNtRNA-dihydrouridine synthase / 0.656
2yww ATPAspartate carbamoyltransferase regulatory chain / 0.656
4dwb 0M7Farnesyl pyrophosphate synthase / 0.656
4cnz ADPNitrogen regulatory protein P-II 1 / 0.655