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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1stc STU cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1stc STUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.093
1nvr STUSerine/threonine-protein kinase Chk1 2.7.11.1 0.906
1nvq UCNSerine/threonine-protein kinase Chk1 2.7.11.1 0.883
1okz UCN3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.851
1u59 STUTyrosine-protein kinase ZAP-70 2.7.10.2 0.828
4c34 STUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.808
2hy8 1STSerine/threonine-protein kinase PAK 1 2.7.11.1 0.787
4wsq KSAAP2-associated protein kinase 1 2.7.11.1 0.776
2j0j 4STFocal adhesion kinase 1 2.7.10.2 0.773
3ckx STUSerine/threonine-protein kinase 24 2.7.11.1 0.761
3cbl STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.747
4mvf STUCalcium-dependent protein kinase 2 2.7.11.1 0.746
2dq7 STUTyrosine-protein kinase Fyn 2.7.10.2 0.745
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4u97 STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.742
3bkb STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.733
4u9a STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.727
2j0m 4STFocal adhesion kinase 1 2.7.10.2 0.721
1byg STUTyrosine-protein kinase CSK / 0.720
3cd3 STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.719
5e8y STUTGF-beta receptor type-2 2.7.11.30 0.718
1q3d STUGlycogen synthase kinase-3 beta 2.7.11.26 0.713
2nry STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.709
1aq1 STUCyclin-dependent kinase 2 2.7.11.22 0.708
2yn8 STUEphrin type-B receptor 4 2.7.10.1 0.698
5e8w STUTGF-beta receptor type-1 2.7.11.30 0.696
2clq STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.686
1sm2 STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.681
4qmy STUSerine/threonine-protein kinase 24 2.7.11.1 0.680
2io6 330Wee1-like protein kinase 2.7.10.2 0.673
2vo7 M05cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.666
1yhs STUSerine/threonine-protein kinase pim-1 2.7.11.1 0.661
4e5f 0N7Polymerase acidic protein / 0.660
1xjd STUProtein kinase C theta type 2.7.11.13 0.659
4fr4 STUSerine/threonine-protein kinase 32A 2.7.11.1 0.659
3l9l L9LcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.655
2erz HFScAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.653